Synthesis of conformationally constrained lysine analogues.
Synthesis of conformationally constrained lysine analogues.
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构象受限的赖氨酸类似物的合成。
DOI：
10.1021/jo060210f
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Madalengoitia,JoseS
中科院分区：
文献类型：
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作者：
Ganorkar,Rakesh;Natarajan,Amarnath;Mamai,Ahmed;Madalengoitia,JoseS
报道了两种构象受限的赖氨酸类似物的合成。基于3-氮杂-双环[3.1.0]己烷体系的新型类似物1的合成是由已知的三环3通过八步完成的。类似物 2 的合成由 4-羟基脯氨酸通过八个步骤完成。两种类似物的合成均经过适当保护，用于 Fmoc/Boc 固相肽合成。
The synthesis of two conformationally constrained lysine analogues is reported. The synthesis of the novel analogue1based on the 3-aza-bicyclo[3.1.0]hexane system is accomplished from the known tricycle3in eight steps. The synthesis of the analogue2is accomplished in eight steps from 4-hydroxy proline. Both analogues are synthesized appropriately protected for Fmoc/Boc solid-phase peptide synthesis.