DEATH IN EMBRYONIC SYSTEMS - DEATH OF CELLS IS USUAL ACCOMPANIMENT OF EMBRYONIC GROWTH AND DIFFERENTIATION
DEATH IN EMBRYONIC SYSTEMS - DEATH OF CELLS IS USUAL ACCOMPANIMENT OF EMBRYONIC GROWTH AND DIFFERENTIATION
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DOI：
10.1126/science.154.3749.604
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发表时间：
1966-01-01
期刊：
影响因子：
56.9
通讯作者：
SAUNDERS, JW
中科院分区：
文献类型：
--
作者：
SAUNDERS, JW
细胞死亡和组织、器官和器官系统的破坏是多细胞生物体发育中的正常形态发生事件。因此，胚胎系统中的死亡可以在与生长和分化相同的概念框架内进行探讨。目前的探索表明，胚胎发生过程中的死亡至少在某些情况下是功利目的，其发生受直接细胞和体液环境因素的控制，其正常表达模式的异常提供了许多突变表型的实现机制。它还指出了一些问题的适当表述，这些问题是我们在理解基因转录水平上对死亡的控制、决定和伴随死亡发生的生化事件、处置的途径以及分解的细胞构件的发育意义时所面临的。
Death of cells and the destruction of tissues, organs, and organ systems are programmed as normal morphogenetic events in the development of multicellular organisms. Death in embryonic systems may thus be explored within the same conceptual framework as growth and differentia-tion. The present exploration revealed that death during embryogenesis serves utilitarian goals in some instances, at least, and that its oc-currence is subject to control by factors of the immediate cellular and humoral environment, and that aberrations in its normal pattern of expression provide the mechanism for realization of many mutant phenotypes. It has also pointed toward the appropriate formulation of some of the problems that confront us in understanding the control of death at the level of genetic transcription, the biochemical events which determine and accompany its occurrence, and the pathways of disposition and the developmental significance of disassembled cellular building blocks.