Altered pattern evoked retinal and cortical potentials associated with human senescence.
Altered pattern evoked retinal and cortical potentials associated with human senescence.
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DOI：
10.3109/02713688609000011
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发表时间：
1986
影响因子：
2
通讯作者：
Gary L. Trick;L. R. Trick;Kathleen M. Haywood
中科院分区：
文献类型：
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作者：
Gary L. Trick;L. R. Trick;Kathleen M. Haywood
生理健康的老年人经常表现出视觉缺陷，这是由于眼介质的传输特性和视觉通路中的神经元件的功能特性两者的年龄相关的变化。许多年龄相关的变化，在光学质量的眼介质已被确定，但年龄依赖性的变化，视觉神经生理学尚未明确划定。本研究检测了人类视网膜和视皮层中产生的模式特异性生物电位的年龄相关变化。使用反相（2.0和7.5 rps）模式（7.5 '，15'，30'和60'检查）同时监测模式反转视觉诱发电位（PRVEP）。研究对象为视力在20/30或更好的年轻视力正常人（20-30岁）和健康老年观察者（70-80岁）。所有数据均校正了老年性瞳孔缩小对视网膜照明的影响。两个生物电位的波形特征的显着变化，注意到老年人。PRRP幅度均匀地减少所有的刺激条件。PRVEP振幅降低也被注意到，但比PRRP振幅降低更具刺激特异性。未观察到明显的PRVEP或PRRP潜伏期变化。这些结果表明，在视网膜和视觉皮层的神经元的生理特性的改变与正常老化。
Physiologically healthy elderly individuals often exhibit visual deficits which result from age-related changes in both the transmission characteristics of the ocular media and the functional properties of the neural elements in the visual pathway. Many of the age-related changes in the optical quality of the ocular media have been identified, but the age-dependent variations in visual neurophysiology have not been clearly delineated. This investigation examined age-related alterations in pattern-specific biopotentials generated in the human retina and visual cortex. Counterphasing (2.0 and 7.5 rps) patterns (7.5', 15', 30' and 60' checks) were used to simultaneously monitor pattern-reversal visual evoked potentials (PRVEPs). Young visual normals (20-30 years of age) and healthy elderly observers (70-80 years of age) with visual acuity of 20/30 or better were studied. All data were corrected for the effects of senile miosis on retinal illumination. Significant variations in the waveform characteristics of both biopotentials were noted for the elderly individuals. PRRP amplitude was uniformly reduced for all stimulus conditions. PRVEP amplitude reductions were also noted but were more stimulus specific than the PRRP amplitude reductions. No significant PRVEP or PRRP latency changes were observed. These results suggest that alterations in the physiological properties of neural elements in both the retina and visual cortex are associated with normal aging.