Health-related quality of life: Changes in children undergoing chemotherapy
Health-related quality of life: Changes in children undergoing chemotherapy
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DOI：
10.1097/mph.0b013e3181647bda
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发表时间：
2008-04-01
影响因子：
1.2
通讯作者：
Klaassen, Robert
中科院分区：
文献类型：
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作者：
Banks, Brie Ann;Barrowman, Nicholas J.;Klaassen, Robert
背景：关于化疗期间儿童健康相关生活质量（HRQL）变化的信息很少。此外，对于哪些措施最适合评估这一人群的HRQL变化，普遍缺乏共识。本研究的目的是比较3个儿科HRQL指标的反应性：儿科生活质量量表（PedsQL）、儿童健康问卷（CHQ）和健康效用指数（HUI）。连续儿科肿瘤患者及其父母每隔1周完成问卷调查，共持续4周，结果：29例患者入组，其中大多数（62%）被诊断为白血病，平均年龄为9岁。从时间1至时间4的母代代理报告显示，通用核心量表的PedsQL平均变化为17，癌症特异性模块为12。CHQ身体功能量表的平均变化为6，而心理社会量表仅为2，而HUI 2为3（x 100），HUI 3为4（x 100）。与HUI 2和3以及CHQ心理社会量表相比，PedsQL通用评分的变化显著更大（P < 0.01）。结论：在异质性人群中重复测量HRQL时，PedsQL是对变化最敏感的测量。
Background: Information regarding changes in the health-related quality of life (HRQL) of children during chemotherapy is scarce. Furthermore, there exists a general lack of consensus as to which measures are best suited to assess changes in HRQL in this population. The purpose of this study is to compare the responsiveness of 3 pediatric HRQL measures: the Pediatric Quality of Life Inventory (PedsQL), the Child's Health Questionnaire (CHQ), and the Health Utilities Index (HUI).Methods: Consecutive pediatric oncology patients and their parents completed the questionnaires at 1-week intervals for a total of 4 weeks, starting on the third day of the patient's chemotherapy treatment cycle.Results: Twenty-nine patients were enrolled with the majority (62%) having a diagnosis of leukemia with an average age of 9 years. The parent proxy reports from time I to 4 showed a mean change in the PedsQL of 17 for the generic core scale and 12 for the cancer specific module. The mean change in CHQ physical functioning scale was 6, while the psychosocial scale was only 2, while the HUI 2 was 3 ( x 100), and HUI 3 was 4 ( x 100). There was significantly more change in the PedsQL generic scores when compared with the HUI 2 and 3 and the CHQ psychosocial scale (P < 0.01).Conclusions: When measuring HRQL repeatedly in a heterogeneous population, the PedsQL is the measure most responsive to change.