SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion
SOX9 is expressed in human fetal prostate epithelium and enhances prostate cancer invasion
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DOI：
10.1158/0008-5472.can-07-5915
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发表时间：
2008-03-15
期刊：
影响因子：
11.2
通讯作者：
Yuan, Xin
中科院分区：
文献类型：
--
作者：
Wang, Hongyun;Leav, Irwin;Yuan, Xin
SOX 9是一种转录因子，在多种组织的发育中起着关键作用。我们以前报道过SOX 9在正常成人前列腺中仅限于基底上皮。SOX 9也在前列腺癌（PCa）细胞亚群中表达，并且在复发性难治性PCa中表达增加。此外，SOX 9在PCa细胞系中的表达增强了肿瘤细胞增殖，并且受到β-连环蛋白的调节。在这里，我们报告额外的体内结果显示，SOX 9是高度表达的胎儿前列腺发育过程中的上皮细胞扩展到间充质，这表明它可能有助于在PCa的侵袭性生长。事实上，LNCaP PCa异种移植物中的S 0X 9过表达增强了生长、血管生成和侵袭。相反，短发夹RNA介导的SOX 9抑制抑制CWR 22 Rv 1 PCa异种移植物的生长。这些结果支持SOX 9在正常前列腺的发育和维持中的重要功能，并表明这些功能有助于PCa肿瘤的生长和侵袭。
SOX9 is a transcription factor that plays a critical role in the development of multiple tissues. We previously reported that SOX9 in normal human adult prostate was restricted to basal epithelium. SOX9 was also expressed in a subset of prostate cancer (PCa) cells and was increased in relapsed hormone-refractory PCa. Moreover, SOX9 expression in PCa cell lines enhanced tumor cell proliferation and was beta-catenin regulated. Here we report additional in vivo results showing that SOX9 is highly expressed during fetal prostate development by epithelial cells expanding into the mesenchyme, suggesting it may contribute to invasive growth in PCa. Indeed, SOX9 overexpression in LNCaP PCa xenografts enhanced growth, angingenesis, and invasion. Conversely, short hairpin RNA-mediated SOX9 suppression inhibited the growth of CWR22Rv1 PCa xenografts. These results support important functions of SOX9 in both the development and maintenance of normal prostate, and indicate that these functions contribute to PCa tumor growth and invasion.