Influence of Genospecies of Acinetobacter baumannii Complex on Clinical Outcomes of Patients with Acinetobacter Bacteremia
Influence of Genospecies of Acinetobacter baumannii Complex on Clinical Outcomes of Patients with Acinetobacter Bacteremia
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DOI：
10.1093/cid/ciq154
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发表时间：
2011-02-01
影响因子：
11.8
通讯作者：
Chang, Shan-Chwen
中科院分区：
文献类型：
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作者：
Chuang, Yu-Chung;Sheng, Wang-Huei;Chang, Shan-Chwen
背景鲍曼不动杆菌复合菌感染的患病率正在增加，并且与高死亡率相关。生化分类试验不能区分A.鲍曼不动杆菌（基因种2）与其他基因种。基因种分型提供了一个潜在的工具，以确定是否有重大差异的致病性之间的基因种。成人A.从2007年1月至2009年7月前瞻性观察重症监护病房的鲍曼不动杆菌复合菌血症。A.通过生化方法和Phoenix细菌鉴定系统鉴定鲍曼不动杆菌复合物。通过16 S-23 S核糖体RNA基因间区序列分析鉴定基因种。135例A.鲍曼不动杆菌复合菌血症中，87株（64.4%）分离株属于基因种2，36株（26.7%）分离株属于基因种13 TU，12株（8.9%）分离株属于基因种3。A.鲍曼不动杆菌（基因种2）菌血症比基因种13 TU菌血症患者更易患肺炎（63.2%对27.8%; P = 0.001），而基因种13 TU菌血症患者更易患原发性菌血症（69.4%对20.7%; P = 0.001）。
Background. Acinetobacter baumannii complex infections are increasing in prevalence and are associated with a high mortality. Biochemical classification tests cannot differentiate A. baumannii (genospecies 2) from other genospecies. Genospecies typing offers a potential tool to determine whether there are major differences in pathogenicity among the genospecies.Methods. Adult patients with A. baumannii complex bacteremia in intensive care units were prospectively observed from January 2007 through July 2009. A. baumannii complex was identified by biochemical methods and the Phoenix bacterial identification system. Genospecies were identified by 16S-23S ribosomal RNA intergenic-spacer sequencing.Results. Among the 135 patients with A. baumannii complex bacteremia, 87 (64.4%) had isolates that belonged to genospecies 2, 36 (26.7%) had isolates that belonged to genospecies 13TU, and 12 (8.9%) had isolates that belonged to genospecies 3. Patients with A. baumannii (genospecies 2) bacteremia were more likely to have pneumonia than were patients with bacteremia due to genospecies 13TU (63.2 % vs 27.8%; P = .001), whereas patients with bacteremia due to genospecies 13TU were more likely to have primary bacteremia (69.4% vs 20.7%; P