REGULATION OF SULFOTRANSFERASE ACTIVITY BY VITAMIN-K IN MOUSE-BRAIN
REGULATION OF SULFOTRANSFERASE ACTIVITY BY VITAMIN-K IN MOUSE-BRAIN
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DOI：
10.1016/0003-9861(90)90557-f
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发表时间：
1990-02-15
影响因子：
3.9
通讯作者：
LEV, M
中科院分区：
文献类型：
--
作者：
SUNDARAM, KS;LEV, M
We have shown previously that the administration of warfarin to 16-day-old mice results in a significant reduction in levels of sulfatides, and to a lesser degree a reduction of other sphingolipids in brain. Vitamin K stimulates biosynthesis of sulfatides in warfarin-treated mice. We now report that warfarin inhibits brain sulfotransferase activity. This inhibition is reversed by vitamin K. The treatment of normal mice with vitamin K stimulates the activities of sulfotransferase and arylsulfatase and the turnover rate of brain sulfatides. The ability of vitamin K to influence the activity of biosynthetic and catabolic enzymes and the turnover of sulfatides suggests a possible regulatory role for vitamin K in the maturing brain.
