MIPPIE: the mouse integrated protein-protein interaction reference
MIPPIE: the mouse integrated protein-protein interaction reference
复制标题
DOI：
10.1093/database/baaa035
复制
发表时间：
2020-06-04
影响因子：
5.8
通讯作者：
Andrade-Navarro, Miguel A.
中科院分区：
文献类型：
--
作者：
Alanis-Lobato, Gregorio;Mollmann, Jannik S.;Andrade-Navarro, Miguel A.
细胞通过一个复杂的蛋白质-蛋白质相互作用（PPIs）网络对环境信号进行操作和反应，该网络的故障会严重破坏细胞的稳态。因此，绘制和分析蛋白质网络是提高我们对生物过程和疾病理解的关键。家鼠（Mus musculus）是这些努力中不可估量的一部分，它是哺乳动物的典范生物，为人类生物学和疾病提供了见解。在小鼠背景下研究PPI网络的重要性促使我们开发了小鼠蛋白质-蛋白质相互作用综合参考（MIPPIE）。MIPPIE继承了其人类ppi姊妹数据库HIPPIE的强大基础设施，允许组装由不同证据来源和高质量实验技术支持的可靠网络。MIPPIE网络可以通过用户友好的网络界面进一步细化组织、方向性和效果信息。此外，所有的MIPPIE数据和元数据都可以通过REST web服务访问或作为文本文件下载，从而促进了小鼠ppi与后续生物信息学管道的整合。
Cells operate and react to environmental signals thanks to a complex network of protein-protein interactions (PPIs), the malfunction of which can severely disrupt cellular homeostasis. As a result, mapping and analyzing protein networks are key to advancing our understanding of biological processes and diseases. An invaluable part of these endeavors has been the house mouse (Mus musculus), the mammalian model organism par excellence, which has provided insights into human biology and disorders. The importance of investigating PPI networks in the context of mouse prompted us to develop the Mouse Integrated Protein-Protein Interaction rEference (MIPPIE). MIPPIE inherits a robust infrastructure from HIPPIE, its sister database of human PPIs, allowing for the assembly of reliable networks supported by different evidence sources and high-quality experimental techniques. MIPPIE networks can be further refined with tissue, directionality and effect information through a user-friendly web interface. Moreover, all MIPPIE data and meta-data can be accessed via a REST web service or downloaded as text files, thus facilitating the integration of mouse PPIs into follow-up bioinformatics pipelines.