Differential role of the dorsal hippocampus, ventro-intermediate hippocampus, and medial prefrontal cortex in updating the value of a spatial goal
Differential role of the dorsal hippocampus, ventro-intermediate hippocampus, and medial prefrontal cortex in updating the value of a spatial goal
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DOI：
10.1002/hipo.22094
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发表时间：
2013-05-01
期刊：
影响因子：
3.5
通讯作者：
Chaillan, Franck A.
中科院分区：
文献类型：
--
作者：
Blanquat, Paul De Saint;Hok, Vincent;Chaillan, Franck A.
在执行地点导航任务时，对特定值的目标进行编码涉及内侧前额叶皮层 (mPFC) 和背侧海马 (dHPC)，并且取决于 mPFC 和腹中间海马 (vHPC) 之间的协调。目前的工作研究了当大鼠必须更新目标值时 mPFC、dHPC 和 vHPC 的贡献。老鼠被训练导航到无提示的目标，以便在连续的位置导航任务中释放食物颗粒。当他们在任务中达到标准表现水平时，他们会接受一次闪光训练，在目标访问期间他们会暴露在令人厌恶的闪光灯下，而不是获得食物奖励。在快闪训练之前，注射 GABAA 激动剂蝇蕈醇以暂时灭活 mPFC、dHPC 或 vHPC。第二天测试了回忆目标变化值的能力。我们首先证明了频闪灯的厌恶效应，通过证明老鼠在闪光会话中比在简单的灭绝会话中更快地学会避开目标，在简单的灭绝会话中，目标访问没有得到奖励。此外，虽然 dHPC 失活对学习和回忆新目标值没有影响，但注射 vHPC 蝇蕈醇会大大延迟闪现过程中的目标值更新，从而导致回忆过程中出现轻微缺陷。相比之下，mPFC 蝇蕈醇注射诱导更快的目标值更新，但大鼠第二天回忆新目标值的能力明显受损。这些结果表明，与 mPFC 和 dHPC 相反，vHPC 是更新目标值所必需的。相比之下，mPFC 对于长期保留这种更新是必要的。 (c) 2013 年 Wiley 期刊公司。
Encoding of a goal with a specific value while performing a place navigation task involves the medial prefrontal cortex (mPFC) and the dorsal hippocampus (dHPC), and depends on the coordination between mPFC and the ventro-intermediate hippocampus (vHPC).The present work investigates the contribution of mPFC, dHPC, and vHPC when the rat has to update the value of a goal. Rats were trained to navigate to an uncued goal in order to release a food pellet in a continuous place navigation task. When they had reached criterion performance level in the task, they were subjected to a single flash session in which they were exposed to an aversive strobe light during goal visits instead of receiving a food reward. Just before the flash session, the GABAA agonist muscimol was injected to temporarily inactivate mPFC, dHPC, or vHPC. The ability to recall the changed value of the goal was tested on the next day. We first demonstrate the aversive effect of the strobe light by showing that rats learn to avoid the goal much more rapidly in the flash session than during a simple extinction session in which goal visits are not rewarded. Furthermore, while dHPC inactivation had no effect on learning and recalling the new goal value, vHPC muscimol injections considerably delayed goal value updating during the flash session, which resulted in a slight deficit during recall. In contrast, mPFC muscimol injections induced faster goal value updating but the rats were markedly impaired on recalling the new goal value on the next day. These results suggest that, contrary to mPFC and dHPC, vHPC is required for updating the value of a goal. In contrast, mPFC is necessary for long-term retention of this updating. (c) 2013 Wiley Periodicals, Inc.