c-Myc expression is related with cell proliferation and associated with poor clinical outcome in human gastric cancer.
c-Myc expression is related with cell proliferation and associated with poor clinical outcome in human gastric cancer.
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DOI：
10.3346/jkms.1999.14.5.526
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发表时间：
1999-10
影响因子：
4.5
通讯作者：
Kim YD
中科院分区：
文献类型：
--
作者：
Han S;Kim HY;Park K;Cho HJ;Lee MS;Kim HJ;Kim YD
我们采用免疫组化方法检测了76例胃癌组织中Myc蛋白的表达。采用流式细胞仪检测细胞增殖指数，分析Myc蛋白的表达。Myc蛋白表达水平通过与生物学和临床参数相关来评估。在76例原发性胃癌中，36例（47.4%）观察到Myc的过度表达。Myc蛋白在早期胃癌中的表达率为42.9%。Myc蛋白的表达被证明在低分化癌细胞中更频繁（p=0.043）。然而，Myc蛋白的表达对疾病的进展或程度几乎没有影响。Myc蛋白的表达与增殖活性的增加显著相关（p=0.032），并且具有高水平Myc表达的患者的无病生存率差。在一定比例的人胃癌中，Myc蛋白可能起着调节癌细胞生长的作用，Myc的表达可能代表胃癌的侵袭表型。
We underwent protein assay for Myc expression in 76 human gastric cancer tissues using immunohistochemistry. Expression of Myc protein was analyzed according to proliferative indices measured by flow cytometry. Levels of Myc protein expression was evaluated by correlating with biologic and clinical parameters. In 36 (47.4%) of 76 primary gastric cancers, overexpression of Myc was observed. We could observe expression of Myc protein in a significant portion of early gastric cancer (42.9%). Expression of Myc protein was demonstrated to be more frequent in poorly differentiated cancer cells (p=0.043). However, expression of Myc protein had little influence over progress or extent of the disease. Expression of Myc protein was significantly correlated with increased proliferative activity (p=0.032) and patients with high levels of Myc expression had poor disease-free survival. In a certain proportion of human gastric cancer, Myc protein may function as a regulator of cancer cell growth and expression of Myc may represent an aggressive phenotype of gastric cancer.