Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats
Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats
复制标题
海藻低分子量硫酸化多糖对甘油所致大鼠急性肾损伤的肾脏保护作用
DOI：
10.1016/j.ijbiomac.2016.11.051
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发表时间：
2017-02-01
影响因子：
8.2
通讯作者：
Zhang, Quanbin
中科院分区：
文献类型：
--
作者：
Li, Xinpeng;Wang, Jing;Zhang, Quanbin
研究海带低分子硫酸多糖（LMWSP）对大鼠甘油致急性肾损伤（AKI）的保护作用。甘油处理显著提高血清肌酐（SCr）和尿素氮（BUN）水平。腹腔注射LMWSP组分可显著降低SCr和BUN水平，减轻肾肿胀。1.0 M NaCl在减轻AKI和维持血糖方面的肾保护作用最好。(C) 2016 Elsevier B.V.版权所有
We investigated the renal protective effect of low-molecular-weight sulfated polysaccharide (LMWSP) fractions extracted from Laminaria japonica on glycerol-induced acute kidney injury (AKI) in rats. Glycerol treatment significantly increased serum creatinine (SCr) and blood urea nitrogen (BUN) levels. Intraperitoneal injection of LMWSP fractions markedly decreased SCr and BUN levels and reduced renal swelling. The fraction of 1.0 M NaCl displayed the best renal protective effect of all fractions in attenuating AKI and maintaining blood glucose. (C) 2016 Elsevier B.V. All rights reserved.