AMYGDALOID NORADRENALINE IS INVOLVED IN THE SENSITIZATION OF THE ACOUSTIC STARTLE RESPONSE IN RATS
AMYGDALOID NORADRENALINE IS INVOLVED IN THE SENSITIZATION OF THE ACOUSTIC STARTLE RESPONSE IN RATS
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DOI：
10.1016/0091-3057(94)90532-0
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发表时间：
1994-06-01
影响因子：
3.6
通讯作者：
SCHNITZLER, HU
中科院分区：
文献类型：
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作者：
FENDT, M;KOCH, M;SCHNITZLER, HU
本研究探讨了杏仁中央核（cA）内去甲肾上腺素（NA）在大鼠声惊吓反应（ASR）增敏中的作用。在第一个实验中，局部注射0，0.5，1，2 nmol的α（2）-肾上腺素能拮抗剂育亨宾到cA增加ASR的幅度在剂量依赖性的方式。在第二个实验中，施加足部电击以增加ASR幅度（致敏）。局部注射0、4、8、16 nmol α（2）-肾上腺素能激动剂ST-91可剂量依赖性地降低足电击对ASR幅度的增敏作用。研究表明育亨宾通过作用于突触前自身感受器而增加局部NA释放，ST-91通过作用于突触前自身感受器而减少局部NA释放。目前的数据表明，NA在cA的释放参与调解的致敏作用的足冲击的ASR。
The present study examined the role of noradrenaline (NA) in the central nucleus of the amygdala (cA) in the sensitization of the acoustic startle response (ASR) in rats. In the first experiment, local microinjections of 0, 0.5, 1, 2 nmol of the alpha(2)-adrenergic antagonist yohimbine into the cA increased the magnitude of the ASR in a dose-dependent way. In the second experiment, foot shocks were applied to increase the ASR amplitude (sensitization). Local microinjections of 0, 4, 8, 16 nmol of the alpha(2)-adrenergic agonist ST-91 into the cA dose dependently decreased the sensitizing effects of foot shocks on the amplitude of the ASR. It is conjectured that yohimbine increases and ST-91 decreases local NA release by acting at presynaptic autoreceptors. The present data suggest that the release of NA in the cA is involved in the mediation of the sensitizing effects of foot shocks on the ASR.