Predictors of freezing in Parkinson's disease:: A survey of 6,620 patients
Predictors of freezing in Parkinson's disease:: A survey of 6,620 patients
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DOI：
10.1002/mds.21458
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发表时间：
2007-05-15
影响因子：
8.6
通讯作者：
Ellgring, Heiner
中科院分区：
文献类型：
--
作者：
Macht, Michael;Kaussner, Yvonne;Ellgring, Heiner
对 6,620 名帕金森病患者的调查数据进行了检查，以了解冻结与年龄、性别、持续时间、帕金森病的主观严重程度以及抗帕金森病药物的相关性。百分之四十七的患者报告经常出现冰冻症状。 Logistic回归分析显示，冷冻与较长的病程和较晚期的疾病显着相关。男性比女性以及服用左旋多巴、恩他卡朋、金刚烷胺或多巴胺激动剂的患者更容易出现冰冻发作。最后，以震颤为主要症状的患者报告冻僵的频率较低。与左旋多巴联合使用的常见抗帕金森病药物与冷冻没有负相关。结果强调了针对这种现象制定适当对策的必要性，众所周知，这种现象会严重损害患者的生活质量，并且正如我们的数据也显示的那样，可能会导致有执照的患者发生交通事故。 (C) 2007 年运动障碍协会。
Data from a survey of 6,620 Parkinson's disease patients were examined for correlation of freezing with age, sex, duration, subjective severity of Parkinson's disease, and antiparkinsonian medication. Forty-seven percent of the patients reported experiencing freezing regularly. Logistic regression analysis showed that freezing was significantly associated with a longer disease duration and a more advanced stage of the disease. Freezing episodes were more likely in men than in women and in patients taking, in addition to levodopa, Entacapone, Amantadine, or dopamine agonists. Finally, patients considering tremor as their main symptom reported freezing less frequently. Common antiparkinsonian drugs given in combination with levodopa were not negatively correlated with freezing. The results underline the necessity to develop appropriate countermeasures against this phenomenon, which is widely known to cause significant impairment of patients' quality of life and-as our data also showed-may cause traffic accidents in licensed patients. (C) 2007 Movement Disorder Society.