Sea urchin sperm exploit extremum seeking control to find the egg
Sea urchin sperm exploit extremum seeking control to find the egg
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DOI：
10.1103/physreve.106.l062401
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发表时间：
2022-12-09
影响因子：
2.4
通讯作者：
Taha, Haithem
中科院分区：
文献类型：
--
作者：
Abdelgalil, Mahmoud;Aboelkassem, Yasser;Taha, Haithem
精子细胞以最小的能力执行极其苛刻的任务。这些细胞必须在嘈杂的环境中快速导航，在没有任何全球定位信息的情况下，在短时间内找到一个卵子，以便成功受精。许多研究工作一直致力于推导数学原理，解释他们高超的导航策略。在这里，我们表明，海胆精子的导航策略，也被称为螺旋klinotaxis，是一个很好的自适应控制范式称为极值寻求一个自然的实现。这种控制理论和微生物趋化生物学之间的桥梁有望加深我们对这一过程的理解。例如，该制剂导致信号通路的粗粒度模型，该模型提供了关于在海胆精子中观察到的高增益和低增益转向模式之间的奇特开关样行为的新见解。此外，它可以指导工程师开发具有最小传感器的生物启发小型机器人。
Sperm cells perform extremely demanding tasks with minimal capabilities. The cells must quickly navigate in a noisy environment to find an egg within a short time window for successful fertilization without any global positioning information. Many research efforts have been dedicated to derive mathematical principles that explain their superb navigation strategy. Here we show that the navigation strategy of sea urchin sperm, also known as helical klinotaxis, is a natural implementation of a well-established adaptive control paradigm known as extremum seeking. This bridge between control theory and the biology of taxis in microorganisms is expected to deepen our understanding of the process. For example, the formulation leads to a coarse-grained model of the signaling pathway that offers new insights on the peculiar switching-like behavior between high -and low-gain steering modes observed in sea urchin sperm. Moreover, it may guide engineers in developing bioinspired miniaturized robots with minimal sensors.