EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue
EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue
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DOI：
10.1006/geno.1998.5491
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发表时间：
1998-10-15
期刊：
影响因子：
4.4
通讯作者：
Lipp, M
中科院分区：
文献类型：
--
作者：
Gräler, MH;Bernhardt, G;Lipp, M
受体构成了一个新的亚家族的G蛋白偶联受体显示异质性表达模式。最近的研究表明，该家族的四个成员，迄今已确定可以结合溶血磷脂或lysosphingolipids作为配体。在这里，我们报告的EDG 6，EDG受体家族的新成员，在体外分化的人和小鼠树突状细胞分离的鉴定和表征。EDG6在胎儿和成人淋巴和造血组织以及肺中特异性表达。edg6的表达模式在人和小鼠中是高度保守的。将人edg6基因定位于染色体19p13.3的D19S120标记处。考虑到edg6的淋巴特异性表达模式和与磷脂结合EDG受体家族的强同一性，我们提出EDG6也可以作为脂质衍生配体的受体。由于已知的生物活性脂质的促有丝分裂和趋化活性，我们认为EDG6可能在淋巴细胞信号传导中发挥重要作用。(C)北京：科学出版社.
receptors constitute a novel subfamily of G-protein-coupled receptors displaying a heterogeneous expression pattern. It was shown recently that the four members of this family thus far identified can bind lysophospholipids or lysosphingolipids as ligands. Here we report the identification and characterization of EDG6, a novel member of the EDG receptor family, isolated from in vitro differentiated human and murine dendritic cells. EDG6 is specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. The expression pattern of edg6 is strongly conserved in human and mouse. The human edg6 gene was mapped to chromosome 19p13.3 at the D19S120 marker. Considering the lymphoid-specific expression pattern of edg6 and the strong identity to the phospholipid-binding EDG; receptor family, we propose that EDG6 may also act as a receptor for a lipid-derived ligand. Because of the known mitogenic and chemotactic activity of bioactive lipids, we believe that EDG6 may play an essential role in lymphocyte cell signaling. (C) 1998 Academic Press.