Type-specific antiviral antibodies to genital human papillomavirus types in mothers and newborns
Type-specific antiviral antibodies to genital human papillomavirus types in mothers and newborns
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DOI：
10.1177/1933719107309546
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发表时间：
2007-12-01
影响因子：
2.9
通讯作者：
Hoepfl, Reinhard
中科院分区：
文献类型：
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作者：
Heim, Kurt;Hudelist, Gernot;Hoepfl, Reinhard
人乳头瘤病毒（hpv）的类型特异性抗体可以在大多数感染的成人患者中检测到，并且它们具有病毒中和特性。然而，缺乏关于母体和新生儿HPV衣壳抗原抗体的血清阳性率的信息。采用酶联免疫吸附试验（ELISA）分析了104名母亲、新生儿和3名双胞胎孕妇的血清中针对HPV-6、-11、-16、-18和-31病毒样颗粒的特异性IgG、IgM和IgA抗体的存在。HPV 6型、11型、16型、18型和31型孕妇IgG阳性率分别为23.1%、2.9%、8.7%、3.8%和9.6%。新生儿发病率无显著性差异，母亲及其婴儿和所有成对双胞胎的IgG ELISA值显示出非常高的相关性。相比之下，新生儿中几乎所有的IgM和IgA个体值都被指定为阴性，而母亲的阳性率高达19.2%。婴儿在出生时或4年随访时均未出现hpv相关病变。在随访检查中，8名接受检测的儿童中有7名失去了HPV IgG抗体。母亲和新生儿中相似的抗HPV IgG血清阳性，新生儿IgA和IgM缺乏，以及双胞胎和随访结果表明，新生儿IgG不是宫内HPV感染的标志，而是母胎抗体传播的标志。
Type-specific antibodies to human papillomaviruses (HPVs) can be detected in most infected adult patients, and they have virus-neutralizing properties. However, there is a dearth of information on the seroprevalence of maternal and neonatal antibodies to HPV capsid antigens. Sera from 104 mothers, their newborns, and 3 twin pregnancies were analyzed by an enzyme-linked immunosorbent assay (ELISA)for the presence of specific IgG, IgM, and IgA antibodies to virus-like particles of HPV-6, -11, -16, -18, and -31. Maternal IgG positivity rates to HPV types 6, 11, 16, 18, and 31 were 23.1%, 2.9%, 8.7%, 3.8%, and 9.6%, respectively. Neonatal rates did not differ significantly, and individual IgG ELISA values of mothers and their infants and all paired twins showed a very high correlation. In contrast, nearly all IgM and IgA individual values in newborns were designated negative, whereas mothers' positivity rates ranged as high as 19.2%. Infants showed no HPV-related lesions at birth or at 4-year follow-up. Seven of 8 tested children lost IgG HPV antibodies in a follow-up examination. Similar anti-HPV IgG seropositivity in mothers and newborns and a lack of neonatal IgA and IgM together with twin and follow-up results indicate that neonatal IgG is not a sign of intrauterine HPV infection but, rather, maternofetal antibody transmission.