Inflammation as a contributing factor among postmenopausal Saudi women with osteoporosis.
Inflammation as a contributing factor among postmenopausal Saudi women with osteoporosis.
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炎症作为沙特绝经后骨质疏松女性的一个影响因素 。
DOI：
10.1097/md.0000000000005780
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发表时间：
2017-01
期刊：
影响因子：
1.6
通讯作者：
Al-Badr FBM
中科院分区：
文献类型：
--
作者：
Al-Daghri NM;Aziz I;Yakout S;Aljohani NJ;Al-Saleh Y;Amer OE;Sheshah E;Younis GZ;Al-Badr FBM
绝经后骨质疏松症是发生在绝经后的一种重要的代谢性骨疾病，其特征是骨快速丢失。最近，临床上显著的骨质减少和骨质疏松症的最普遍形式涉及各种炎性病症。本研究的目的是评价促炎性标志物（白细胞介素[IL]-1β、IL-6、TNF-α）与绝经后沙特妇女（有和无骨质疏松症）骨转换标志物（BTM）之间的相关性。在沙特阿拉伯利雅得萨勒曼国王医院和法赫德国王医疗城的合格医生的监督下，共招募了200名年龄≥50岁的绝经后沙特女性，其中100名患有骨质疏松症，100名没有骨质疏松症（对照）。采用Luminex xMAP技术测定血清肿瘤坏死因子α（TNF-α）、IL-1、IL-4、IL-6和甲状旁腺激素（PTH）。采用酶联免疫吸附试验（ELISA）测定I型胶原N端肽（NTx），电化学发光法测定25（OH）维生素D和骨钙素，化学分析仪测定血清钙和无机磷（Pi）。骨质疏松症患者血清IL-1β、IL-6、NTx和PTH水平显著高于对照组。IL-4和骨钙素水平明显低于对照组。IL-1β、TNF-α与NTx呈正相关。两组TNF-α、IL-6、TNF-α与IL-1 β均呈正相关。骨钙素与IL-1β在健康妇女和骨质疏松妇女中呈显著负相关。本研究的发现暗示了骨质疏松症患者中细胞因子模式介导的炎症的作用。
Postmenopausal osteoporosis is an important metabolic bone disease characterized by rapid bone loss occurring in the postmenopausal period. Recently, the most prevalent form of clinically significant osteopenia and osteoporosis involves various inflammatory conditions. The aim of the study is to evaluate the association between proinflammatory markers (interleukin [IL]-1β, IL-6, TNF-α) with bone turnover markers (BTMs) in postmenopausal Saudi women with and without osteoporosis. A total of 200 postmenopausal Saudi women ≥50 years old, 100 with osteoporosis and 100 without osteoporosis (control) were recruited under the supervision of qualified physicians in King Salman Hospital and King Fahd Medical City, Riyadh, Saudi Arabia. Serum tumor necrosis factor alpha (TNF-α), IL-1, IL-4, IL-6, and parathyroid hormone (PTH) were determined using Luminex xMAP technology. N-telopeptides of collagen type I (NTx) was assessed using ELISA, 25(OH) vitamin D and osteocalcin were determined using electrochemiluminescence, serum calcium and inorganic phosphate (Pi) were measured by a chemical analyzer. Serum IL-1β, IL-6, NTx, and PTH levels in women with osteoporosis were significantly higher than controls. Although IL-4 and osteocalcin were significantly lower than controls. IL-1β and TNF-α were positively associated with NTx in osteoporosis women. TNF-α, IL-6, and TNF-α were positively correlated with IL-lβ in both groups. A significant negative correlation between osteocalcin and IL-1β in healthy women and women with osteoporosis were observed. Findings of the present study implicate a role for cytokine pattern-mediated inflammation in patients with osteoporosis.