Pattern recognition receptors in innate immunity, host defense, and immunopathology.
Pattern recognition receptors in innate immunity, host defense, and immunopathology.
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DOI：
10.1152/advan.00058.2013
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发表时间：
2013-12
影响因子：
2.1
通讯作者：
Rahul Suresh;D. Mosser
中科院分区：
文献类型：
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作者：
Rahul Suresh;D. Mosser
病原微生物的感染引发病原体和宿主之间由模式识别受体介导的一系列复杂的相互作用。在感染的早期阶段，先天免疫应答在宿主防御中发挥直接作用，并且它们还对随后的适应性免疫应答的产生深远的影响。对介导先天反应的模式识别受体及其受体连接后的下游效应的更好理解有可能导致改进疫苗和预防自身免疫的新方法。本文综述了先天免疫激活的控制和先天免疫受体在帮助维持组织稳态中的作用。
Infection by pathogenic microbes initiates a set of complex interactions between the pathogen and the host mediated by pattern recognition receptors. Innate immune responses play direct roles in host defense during the early stages of infection, and they also exert a profound influence on the generation of the adaptive immune responses that ensue. An improved understanding of the pattern recognition receptors that mediate innate responses and their downstream effects after receptor ligation has the potential to lead to new ways to improve vaccines and prevent autoimmunity. This review focuses on the control of innate immune activation and the role that innate immune receptors play in helping to maintain tissue homeostasis.