Enhanced bone apposition to a chemically modified SLA titanium surface
Enhanced bone apposition to a chemically modified SLA titanium surface
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DOI：
10.1177/154405910408300704
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发表时间：
2004-07-01
影响因子：
7.6
通讯作者：
Steinemann, SG
中科院分区：
文献类型：
--
作者：
Buser, D;Broggini, N;Steinemann, SG
牙种植体表面粗糙度的增加显示了更多的骨结合；然而，表面化学修饰的效果仍不清楚。在本研究中，我们评估了在骨再生的早期阶段，改良喷砂/酸蚀(ModSLA)钛表面与标准SLA表面的骨结合情况。在小型猪身上放置实验性种植体，造成2个环状骨缺损。试验种植体和对照种植体具有相同的表面形貌，但表面化学成分不同。我们在酸蚀后将植入物浸入等渗的氯化钠溶液中，以避免受到大气中分子的污染，从而创建了测试表面。在愈合2周(49.30%比29.42%；p=0.017)和4周(81.91%比66.57%；p=0.011)时，测试植入物显示出明显高于对照组的骨-植入物接触的平均百分比。在8周时，观察到了类似的结果。结论：在骨再生的早期阶段，modSLA表面促进了骨沉积的增强。
Increased surface roughness of dental implants has demonstrated greater bone apposition; however, the effect of modifying surface chemistry remains unknown. In the present study, we evaluated bone apposition to a modified sandblasted/acid-etched (modSLA) titanium surface, as compared with a standard SLA surface, during early stages of bone regeneration. Experimental implants were placed in miniature pigs, creating 2 circular bone defects. Test and control implants had the same topography, but differed in surface chemistry. We created the test surface by submerging the implant in an isotonic NaCl solution following acid-etching to avoid contamination with molecules from the atmosphere. Test implants demonstrated a significantly greater mean percentage of bone-implant contact as compared with controls at 2 (49.30 vs. 29.42%; p = 0.017) and 4 wks (81.91 vs. 66.57%; p = 0.011) of healing. At 8 wks, similar results were observed. It is concluded that the modSLA surface promoted enhanced bone apposition during early stages of bone regeneration.