Hair follicle epidermal stem cells define a niche for tactile sensation.
Hair follicle epidermal stem cells define a niche for tactile sensation.
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DOI：
10.7554/elife.38883
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发表时间：
2018-10-25
期刊：
影响因子：
7.7
通讯作者：
Fujiwara H
中科院分区：
文献类型：
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作者：
Cheng CC;Tsutsui K;Taguchi T;Sanzen N;Nakagawa A;Kakiguchi K;Yonemura S;Tanegashima C;Keeley SD;Kiyonari H;Furuta Y;Tomono Y;Watt FM;Fujiwara H
干细胞的异质性和区室化是许多上皮细胞中的共同原则，并且已知其在上皮维持中起作用，但其其他生理作用仍然难以捉摸。在这里，我们显示了在小鼠毛囊触觉感觉单位形成中，区室化表皮干细胞的转录和解剖学贡献。毛囊上隆部的表皮干细胞表达一组独特的细胞外基质（ECM）和神经发生相关基因。这些表皮干细胞存款一种称为EGFL 6的ECM蛋白到衣领基质中，这是一种紧密包裹披针形复合物的新型ECM。EGFL 6是需要适当的图案，触摸响应，和αv整联蛋白富集的披针形复合物。通过维持静止的原始表皮干细胞小生境，旧隆起，表皮干细胞提供解剖学上稳定的毛囊-披针形复合物界面，而不管毛囊再生周期的阶段。因此，区室化的表皮干细胞在整个毛发周期中提供了连接毛囊和神经系统的小生境。
The heterogeneity and compartmentalization of stem cells is a common principle in many epithelia, and is known to function in epithelial maintenance, but its other physiological roles remain elusive. Here we show transcriptional and anatomical contributions of compartmentalized epidermal stem cells in tactile sensory unit formation in the mouse hair follicle. Epidermal stem cells in the follicle upper-bulge, where mechanosensory lanceolate complexes innervate, express a unique set of extracellular matrix (ECM) and neurogenesis-related genes. These epidermal stem cells deposit an ECM protein called EGFL6 into the collar matrix, a novel ECM that tightly ensheathes lanceolate complexes. EGFL6 is required for the proper patterning, touch responses, and αv integrin-enrichment of lanceolate complexes. By maintaining a quiescent original epidermal stem cell niche, the old bulge, epidermal stem cells provide anatomically stable follicle–lanceolate complex interfaces, irrespective of the stage of follicle regeneration cycle. Thus, compartmentalized epidermal stem cells provide a niche linking the hair follicle and the nervous system throughout the hair cycle.