Identifying Metabolically Healthy but Obese Individuals in Sedentary Postmenopausal Women
Identifying Metabolically Healthy but Obese Individuals in Sedentary Postmenopausal Women
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DOI：
10.1038/oby.2009.364
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发表时间：
2010-05-01
期刊：
影响因子：
6.9
通讯作者：
Rabasa-Lhoret, Remi
中科院分区：
文献类型：
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作者：
Messier, Virginie;Karelis, Antony D.;Rabasa-Lhoret, Remi
本研究的目的是比较不同的方法，以确定代谢健康，但肥胖（MHO）的个体在一个队列的肥胖绝经后妇女。我们检查了113名肥胖（年龄：57.3 ± 4.8岁; BMI：34.2 ± 2.7 kg/m2）、久坐的绝经后妇女的人体测量和代谢特征。以下方法用于识别MHO受试者：高胰岛素-正葡萄糖钳夹（MHO：葡萄糖处置率的上四分位数）;松田指数（MHO：Matsuda指数的上四分位数）;稳态模型评估（HOMA）指数（MHO：HOMA指数的下四分位数）;有0-1个心脏代谢异常（收缩压/舒张压>= 130/85 mm Hg，甘油三酯（TG）>= 1.7 mmol/l，葡萄糖>= 5.6 mmol/l，HOMA >5.13，高敏C反应蛋白（hsCRP）>0.1 mg/l，高密度脂蛋白胆固醇（HDL-C）
The purpose of this study was to compare different methods to identify metabolically healthy but obese (MHO) individuals in a cohort of obese postmenopausal women. We examined the anthropometric and metabolic characteristics of 113 obese (age: 57.3 +/- 4.8 years; BMI: 34.2 +/- 2.7 kg/m(2)), sedentary postmenopausal women. The following methods were used to identify MHO subjects: the hyperinsulinemic-euglycemic clamp (MHO: upper quartile of glucose disposal rates); the Matsuda index (MHO: upper quartile of the Matsuda index); the homeostasis model assessment (HOMA) index (MHO: lower quartile of the HOMA index); having 0-1 cardiometabolic abnormalities (systolic/diastolic blood pressure >= 130/85 mm Hg, triglycerides (TG) >= 1.7 mmol/l, glucose >= 5.6 mmol/l, HOMA >5.13, high-sensitive C-reactive protein (hsCRP) >0.1 mg/l, high-density lipoprotein-cholesterol (HDL-C)