Gly82Ser polymorphism of the receptor for advanced glycation end products is associated with an increased risk of gastric cancer in a Chinese population
Gly82Ser polymorphism of the receptor for advanced glycation end products is associated with an increased risk of gastric cancer in a Chinese population
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DOI：
10.1158/1078-0432.ccr-07-4808
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发表时间：
2008-06-01
影响因子：
11.5
通讯作者：
Wang, Bin
中科院分区：
文献类型：
--
作者：
Gu, Haijuan;Yang, Li;Wang, Bin
目的：晚期糖基化终末产物受体（receptor for advanced glycation end products，RECEPTOR）的表达与胃癌的侵袭和转移密切相关。结果表明，在该基因的第3外显子上发现了一个Gly（82）Ser多态性，并认为该多态性影响了该基因蛋白的功能。因此，本研究的目的是探讨该基因多态性是否与胃癌的发生、发展有关。实验设计：采用以医院为基础的病例对照研究，采用PCR-RFLP方法检测566例胃癌患者的HLA-RFLP基因型（283名胃癌患者和283名年龄和性别匹配的对照）。病例组与对照组基因型分布差异有统计学意义（P = 0.038）。与野生型82 Gly/Gly携带者相比，携带变异基因型（82 Gly/Ser和82 Ser/Ser）的受试者患胃癌的风险显著升高（校正比值比，1.47; 95%可信区间，1.05-2.06）。此外，胃癌风险的升高在年轻个体（年龄
Purpose: It has been shown that the expression of the receptor for advanced glycation end products (RAGE) is closely associated with invasion and metastasis in gastric cancer. A Gly(82)Ser polymorphism in exon 3 of RAGE gene was identified and thought to have an effect on the functions of its protein. Therefore, the goal of the present study was to investigate whether the polymorphism is involved in the development or progression of gastric cancer.Experimental Design: In the hospital-based case-control study, the RAGE genotypes were determined using PCR-RFLP in 566 individuals (283 gastric cancer patients and 283 age- and sex-matched controls).Results: The distribution of genotype was significantly different between cases and controls (P = 0.038). Compared with the wild-type 82Gly/Gly carriers, subjects with the variant genotypes (82Gly/Ser and 82Ser/Ser) had a significantly higher risk of gastric cancer (adjusted odds ratio, 1.47; 95% confidence interval, 1.05-2.06). Moreover, the elevated gastric cancer risk was especially evident in younger individuals (ages