Strategy for the Synthesis of Pyrimidine Derivatives: NbCl5-Mediated Cycloaddition of Alkynes and Nitriles
Strategy for the Synthesis of Pyrimidine Derivatives: NbCl5-Mediated Cycloaddition of Alkynes and Nitriles
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DOI：
10.1021/om300669s
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发表时间：
2012-07
期刊：
影响因子：
2.8
通讯作者：
Y. Satoh;Kaoru Yasuda;Y. Obora
中科院分区：
文献类型：
--
作者：
Y. Satoh;Kaoru Yasuda;Y. Obora
利用NbCl_5络合物成功地实现了炔（端炔和内炔）与芳基腈的分子间环加成反应，得到了高产率的取代嘧啶衍生物，具有优异的化学选择性和区域选择性。
Intermolecular cycloadditions of alkynes (terminal alkynes and internal alkynes) with aryl nitriles were successfully achieved, using an NbCl5 complex, to give substituted pyrimidine derivatives in high yields with excellent chemo- and regioselectivity.