Gene expression in NKT cells: defining a functionally distinct CD1d-restricted T cell subset.
Gene expression in NKT cells: defining a functionally distinct CD1d-restricted T cell subset.
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NKT 细胞中的基因表达：定义功能独特的 CD1d 限制性 T 细胞亚群。
DOI：
10.1016/s0952-7915(00)00258-2
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发表时间：
2001
影响因子：
7
通讯作者：
Byrne,MC
中科院分区：
文献类型：
--
作者：
Wilson,SB;Byrne,MC
自从发现NKT细胞作为携带TCR和NK细胞受体的细胞以来，NKT细胞作为先天性免疫和适应性免疫之间的可能桥梁而被深入研究。虽然它们参与各种各样的免疫反应和疾病状态已经有很好的记录，但缺乏这种功能的分子细节。最近，使用微阵列的转录谱已被应用于这些细胞，精确定位这一调节性T细胞亚群和传统T细胞之间的基因表达差异，并提供了一个框架，在临床环境中的亚群特异性治疗干预。
Since their discovery as cells bearing both TCRs and NK cell receptors, NKT cells have been intensively studied as a possible bridge between innate and adaptive immunity. Although their involvement in a wide variety of immune responses and in disease states have been well documented, molecular details of this functionality have been lacking. Recently, transcriptional profiling using microarrays has been applied to these cells, pinpointing gene-expression differences between this regulatory T cell subset and conventional T cells, and providing a framework for subset-specific therapeutic intervention in clinical settings.