Association between changes in frailty during hospitalization in older adults and 3-month mortality after discharge
Association between changes in frailty during hospitalization in older adults and 3-month mortality after discharge
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DOI：
10.1007/s41999-022-00704-7
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发表时间：
2022-10
影响因子：
3.8
通讯作者：
H. Umegaki;M. Nagae;H. Komiya;Kazuhisa Watanabe;Y. Yamada;T. Sakai
中科院分区：
文献类型：
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作者：
H. Umegaki;M. Nagae;H. Komiya;Kazuhisa Watanabe;Y. Yamada;T. Sakai
脆弱是一种动态状态，可以恶化，也可以改善。然而，住院期间发生的脆弱状态的变化及其意义尚未得到全面调查。在这项研究中，我们探索了这种变化与因急性护理而住院的老年人出院后3个月死亡率之间的关系。总共有257名参与者(平均年龄84.95 ± 5.88，其中41.6%为男性)完成了全面的老年评估，包括入院和出院时的临床脆弱度量表(CFS)。入院时CFS值为5.14 ± 1.35。在住院期间，29.2%的参与者(75/257)的CFS评分增加，表明虚弱正在恶化。多元Logistic回归分析显示，住院期间增加的CFS评分与死亡率(优势比，2.987)呈正相关，与潜在的共同发病因素无关。在住院期间这种虚弱的恶化可能是需要急性护理住院的老年人预后不良的可改变的危险因素。
Frailty is a dynamic status that can worsen or improve. However, changes in their frailty status that occur during hospitalization and their significance have not been comprehensively investigated. In this study, we explored the association between such changes and mortality 3 months after discharge in older adults hospitalized for acute care. In total, 257 participants (mean age 84.95 ± 5.88, 41.6% male) completed comprehensive geriatric assessments, including the Clinical Frailty Scale (CFS) at admission and discharge. Mean CFS score was 5.14 ± 1.35 at admission. CFS scores increased, indicating deteriorating frailty, in 29.2% of the participants (75/257) during hospitalization. Multiple logistic regression analysis demonstrated a positive association between increased CFS score during hospitalization and mortality (odds ratio, 2.987) independent of potential co-founding factors. This deterioration in frailty during hospitalization may be modifiable risk factor of poor prognosis in older adults who need acute care hospitalization.