Interstitial fluid flow within bone canaliculi and electro-chemo-mechanical features of the canalicular milieu
Interstitial fluid flow within bone canaliculi and electro-chemo-mechanical features of the canalicular milieu
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DOI：
10.1007/s10237-012-0422-7
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发表时间：
2013-06-01
影响因子：
3.5
通讯作者：
Lemaire, Thibault
中科院分区：
文献类型：
--
作者：
Sansalone, Vittorio;Kaiser, Joanna;Lemaire, Thibault
小管液流被认为在骨功能中发挥重要作用，允许骨细胞的代谢和活性，并为细胞与细胞的通信提供有效的方式。骨小管是贯穿骨固体基质的小管，容纳骨细胞的树突，并被富含离子的间质液饱和。由于这些管道的尺寸很小（直径几百纳米），流体流动与电化学现象相结合。在我们以前的工作中，我们开发了一个多尺度模型占耦合的水力和化学品运输的小管网络。不幸的是，模型所需的大部分物理和几何信息很难通过当今的实验技术获得。本研究的目的是数值评估的物理和材料参数的影响，参与泪小管流体流动。重点放在泪小管环境的电化学机械特征上，希望涵盖任何体内情况。获得了两个主要结果。首先，确定影响泪小管液流的最相关参数，并量化其影响。其次，这些发现被赋予了更大的范围，以涵盖本研究中未考虑的场景。因此，本研究提供了深入了解在骨电化学和力学之间的潜在相互作用，并提供了进一步的理论和实验研究的合理性。
Canalicular fluid flow is acknowledged to play a major role in bone functioning, allowing bone cells' metabolism and activity and providing an efficient way for cell-to-cell communication. Bone canaliculi are small canals running through the bone solid matrix, hosting osteocyte's dendrites, and saturated by an interstitial fluid rich in ions. Because of the small size of these canals (few hundred nanometers in diameter), fluid flow is coupled with electrochemical phenomena. In our previous works, we developed a multi-scale model accounting for coupled hydraulic and chemical transport in the canalicular network. Unfortunately, most of the physical and geometrical information required by the model is hardly accessible by nowadays experimental techniques. The goal of this study was to numerically assess the influence of the physical and material parameters involved in the canalicular fluid flow. The focus was set on the electro-chemo-mechanical features of the canalicular milieu, hopefully covering any in vivo scenario. Two main results were obtained. First, the most relevant parameters affecting the canalicular fluid flow were identified and their effects quantified. Second, these findings were given a larger scope to cover also scenarios not considered in this study. Therefore, this study gives insight into the potential interactions between electrochemistry and mechanics in bone and provides the rational for further theoretical and experimental investigations.