BAGE - A NEW GENE ENCODING AN ANTIGEN RECOGNIZED ON HUMAN MELANOMAS BY CYTOLYTIC T-LYMPHOCYTES
BAGE - A NEW GENE ENCODING AN ANTIGEN RECOGNIZED ON HUMAN MELANOMAS BY CYTOLYTIC T-LYMPHOCYTES
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DOI：
10.1016/s1074-7613(95)80053-0
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发表时间：
1995-02-01
期刊：
影响因子：
32.4
通讯作者：
VANDERBRUGGEN, P
中科院分区：
文献类型：
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作者：
BOEL, P;WILDMANN, C;VANDERBRUGGEN, P
人黑色素瘤 MZ2-MEL 上的自体溶细胞 T 淋巴细胞 (CTL) 可识别多种肿瘤抗原。其中一些由MAGE-1和MAGE-3基因编码，这些基因在除睾丸外的正常组织中不表达。在这里，我们报告了编码另一种抗原的新基因的鉴定。这个名为 SAGE 的基因编码一种推定的 43 个氨基酸的蛋白质，似乎属于多个基因家族。自体 CTL 识别的抗原由 BAGE 编码的肽 AARAVFLAL 与 HLA-Cw*1601 分子结合组成。 BAGE 基因在 22% 的黑色素瘤、30% 的浸润性膀胱癌、10% 的乳腺癌、8% 的头颈鳞状细胞癌和 6% 的非小细胞肺癌中表达。与 MAGE 基因一样，它在除睾丸之外的正常组织中是沉默的。由于其肿瘤特异性表达，BAGE 编码的抗原可能对癌症免疫治疗有用。
Several tumor antigens are recognized by autologous cytolytic T lymphocytes (CTL) on human melanoma MZ2-MEL. Some of them are encoded by genes MAGE-1 and MAGE-3, which are not expressed in normal tissues except in testis. Here, we report the identification of a new gene that codes for another of these antigens. This gene, named SAGE, codes for a putative protein of 43 aa and seems to belong to a family of several genes. The antigen recognized by the autologous CTL consists of BAGE-encoded peptide AARAVFLAL bound to an HLA-Cw*1601 molecule. Gene BAGE is expressed in 22% of melanomas, 30% of infiltrating bladder carcinomas, 10% of mammary carcinomas, 8% of head and neck squamous cell carcinomas, and 6% of non-small cell lung carcinomas. Like the MAGE genes, it is silent in normal tissues with the exception of testis. Because of its tumor-specific expression, the BAGE-encoded antigen may prove useful for cancer immunotherapy.