Absence of mononuclear phagocyte antigens in malignant fibrous histiocytoma.
Absence of mononuclear phagocyte antigens in malignant fibrous histiocytoma.
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恶性纤维组织细胞瘤中缺乏单核吞噬细胞抗原。
DOI：
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发表时间：
1986
影响因子：
3.5
通讯作者：
W. Franklin
中科院分区：
文献类型：
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作者：
M. Brecher;W. Franklin
应用碱性磷酸酶-抗碱性磷酸酶免疫组化法检测9例恶性纤维组织细胞瘤（MFH）中巨噬细胞相关抗原的表达。一个粘液样和八个多形性storiform肿瘤进行了分析，与以前发现的单核吞噬细胞系的细胞上的单独的抗原反应的八种抗体。恶性细胞不与任何抗体反应，而肿瘤内的良性组织细胞一致地标记有所有测试的抗体。虽然恶性细胞MFH先前已被发现与组织细胞共享一些功能和形态学特性，但它们不具有已在各种巨噬细胞群体上发现的表面和细胞质抗原。MFH的恶性细胞是成纤维细胞或低分化间充质细胞，而不是肿瘤性组织细胞。
Nine malignant fibrous histiocytomas (MFHs) were tested for the presence of macrophage-associated antigens by an alkaline phosphatase-anti-alkaline phosphatase immunohistochemical method. One myxoid and eight pleomorphic-storiform tumors were analyzed with eight antibodies reacting with separate antigens previously found on cells of mononuclear phagocyte lineage. Malignant cells did not react with any of the antibodies, while benign histiocytes within tumor were consistently labeled with all of the antibodies tested. While the malignant cells of MFH previously have been found to share some functional and morphologic properties with histiocytes, they do not possess the surface and cytoplasmic antigens that have been found on various macrophage populations. The malignant cells of MFH are fibroblastic or poorly differentiated mesenchymal cells rather than neoplastic histiocytes.