Progression through the RNA polymerase II CTD cycle.
Progression through the RNA polymerase II CTD cycle.
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DOI：
10.1016/j.molcel.2009.10.019
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发表时间：
2009-11-25
期刊：
影响因子：
16
通讯作者：
Buratowski S
中科院分区：
文献类型：
--
作者：
Buratowski S
RNA聚合酶II最大亚基的C末端结构域在转录过程中经历动态磷酸化，在转录的每个阶段占主导地位的不同磷酸化模式招募了适当的一组mRNA处理和组蛋白修饰因子。最近的论文帮助解释了CTD磷酸化模式的变化是如何与从起始到延伸到终止的过程联系在一起的。
The C-terminal domain of the RNA polymerase II largest subunit undergoes dynamic phosphorylation during transcription, and the different phosphorylation patterns that predominate at each stage of transcription recruit the appropriate set of mRNA processing and histone modifying factors. Recent papers help explain how the changes in CTD phosphorylation pattern are linked to the progression from initiation through elongation to termination.