Personality and breast cancer risk and survival: the Miyagi Cohort Study
Personality and breast cancer risk and survival: the Miyagi Cohort Study
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性格与乳腺癌风险和生存：宫城队列研究
DOI：
10.1007/s10549-015-3364-9
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发表时间：
2015
影响因子：
3.8
通讯作者：
Ichiro Tsuji
中科院分区：
文献类型：
--
作者：
Yuko Minami;Toru Hosokawa;Naoki Nakaya;Yumi Sugawara;Yoshikazu Nishino;Yoichiro Kakugawa;Akira Fukao;Ichiro Tsuji
长期以来，人们一直假设性格与乳腺癌风险和生存率有关。目前在日本进行的基于人群的前瞻性队列研究验证了这一假设。为了研究人格与乳腺癌风险的关系，从1990年到2007年，共有15，107名年龄在40-64岁之间的女性完成了艾森克人格量表修订版（EPQ-R）简表。为了评估人格与乳腺癌后生存率的关系，从诊断之日起至2008年，对250例确诊病例进行了进一步随访，记录了45例全因死亡。根据EPQ-R各分量表（外向性、神经质、精神质和说谎）0 - 12分的四分位数，将研究对象分为四组，并使用最低类别作为参考，计算每个类别的风险比（HR）。多变量分析显示，四个人格分量表中的任何一个都与乳腺癌的风险无关。在生存分析中，没有发现任何这些分量表和死亡风险之间的显着关联，尽管具有较高外向性评分的乳腺癌病例往往具有较低的死亡风险（趋势P = 0.07;最高评分水平的HR = 0.38）。排除32例在随访的前3年诊断的病例并没有在很大程度上改变乳腺癌风险或生存率的结果。目前的研究结果表明，性格对乳腺癌的发展和进展没有显着影响。
It has long been hypothesized that personality is associated with breast cancer risk and survival. The present population-based prospective cohort study in Japan tested this hypothesis. To investigate the association of personality with breast cancer risk, a total of 15,107 women aged 40–64 years who completed the Eysenck Personality Questionnaire-Revised (EPQ-R) Short Form were followed from 1990 to 2007. To assess the association of personality with survival after breast cancer, 250 identified cases were further followed up from the date of diagnosis to 2008, and 45 all-cause deaths were documented. Study subjects were categorized into four groups based on the quartile points of scores ranging between 0 and 12 on each EPQ-R subscale (extraversion, neuroticism, psychoticism, and lie), and the hazard ratio (HR) for each category was computed using the lowest category as reference. Multivariate analysis revealed no association between any of the four personality subscales and the risk of breast cancer. In the analysis on survival, no significant association was found between any of these subscales and the risk of death, although breast cancer cases with a higher score of extraversion tended to have a lower risk of death (Pfor trend = 0.07; HR for highest score level = 0.38). Exclusion of 32 cases diagnosed in the first 3 years of follow-up did not largely change the results with regard to either breast cancer risk or survival. The present findings suggest that personality does not impact significantly on the development and progression of breast cancer.