A prospective study of pigmentation, sun exposure, and risk of cutaneous malignant melanoma in women
A prospective study of pigmentation, sun exposure, and risk of cutaneous malignant melanoma in women
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DOI：
10.1093/jnci/djg075
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发表时间：
2003-10-15
期刊：
影响因子：
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通讯作者：
Adami, HO
中科院分区：
文献类型：
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作者：
Veierod, MB;Weiderpass, E;Adami, HO
背景资料：虽然阳光照射是皮肤恶性黑色素瘤的一个确定的原因，可能与宿主因素的相互作用仍然不完全清楚。在这里，我们报告了色素沉着因素和阳光照射与黑色素瘤风险相关的大型前瞻性队列研究的第一个结果。研究方法：妇女的生活方式和健康队列研究包括106379名妇女从挪威和瑞典谁是年龄在30-50岁，在1991年或1992年，当他们完成了广泛的问卷调查个人特征和曝光。与国家登记册的联系确保了1999年12月31日之前的完整后续行动。Poisson回归模型用于估计相对风险（RR）。所有统计检验均为双侧检验。结果：在平均8.1年的随访中，诊断出187例黑色素瘤。黑色素瘤的风险在统计学上与体表面积的增加显著相关（大于或等于1.79 m（2）与小于或等于1.61 m（2）的RR = 1.60，95%置信区间[CI] = 1.03至2.48; P-趋势= 0.02），腿部大的不对称痣数量（大于或等于7个痣与0个痣的RR = 5.29，95% CI = 2.33至12.01; P-趋势
Background: Although sun exposure is an established cause of cutaneous malignant melanoma, possible interactions with host factors remain incompletely understood. Here we report the first results from a large prospective cohort study of pigmentation factors and sun exposure in relation to melanoma risk. Methods: The Women's Lifestyle and Health Cohort Study included 106379 women from Norway and Sweden who were aged 30-50 years in 1991 or 1992 when they completed an extensive questionnaire on personal characteristics and exposures. Linkages to national registries ensured complete follow-up through December 31, 1999. Poisson regression models were used to estimate relative risks (RRs). All statistical tests were two-sided. Results: During an average follow-up of 8.1 years, 187 cases of melanoma were diagnosed. Risk of melanoma was statistically significantly associated with increasing body surface area (RR for greater than or equal to1.79 m(2) versus less than or equal to1.61 m(2) = 1.60, 95% confidence interval [CI] = 1.03 to 2.48; P-trend = .02), number of large asymmetric nevi on the legs (RR for greater than or equal to7 nevi versus 0 nevi = 5.29, 95% CI = 2.33 to 12.01; P-trend