Synaptic vesicle morphology: a case of protein sorting?

Synaptic vesicle morphology: a case of protein sorting?
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突触小泡形态:蛋白质分选的一个案例?

DOI:
10.1016/j.ceb.2013.09.001
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发表时间:
2014
影响因子:
7.5
通讯作者:
Bai,Jihong
Bai,Jihong
中科院分区:
生物学2区
文献类型:
--
作者:
Poudel,KumudR;Bai,Jihong

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Synaptic vesicles (SVs) are the repositories of neurotransmitters. They are locally recycled at nerve terminals following exocytosis. A unique feature of these vesicles is the uniformity of their morphology, which is well maintained even after rounds of exocytosis and endocytosis. Several studies suggest that disruption of clathrin adaptor proteins leads to defects in sorting cargoes and alterations in SV morphology. Here, we review the links between adaptor proteins and SV size, and highlight how protein sorting may impact SV architecture. Molecular players such as clathrin, adaptor proteins, accessory proteins, SV cargoes and lipid composition may act together to establish a stable regulatory network to maintain SV morphology.
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