The rediscovery of thiamine deficiency disorders at a secondary level mission hospital in Northeast India
The rediscovery of thiamine deficiency disorders at a secondary level mission hospital in Northeast India
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DOI：
10.1111/nyas.14552
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发表时间：
2020-12-31
影响因子：
5.2
通讯作者：
Solomi, Carolin V.
中科院分区：
文献类型：
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作者：
Koshy, Roshine Mary;Thankaraj, Shajin;Solomi, Carolin V.
在这篇文章中，我们报告了在印度东北部偏远农村教会医院看到的硫胺素缺乏症的不同表现，包括调查、治疗和康复。两个案例研究，一个是患有心脏性脚气的婴儿，另一个是非酒精性成人，表现为周围神经病变、心肌病和代谢性酸中毒，并对补充硫胺素有反应，详细描述。我们与这些临床实体分享了过去二十年来的经验，包括最近的研究和吸取的教训，并提出了确定印度东北部高危人群、改善早期诊断和治疗以及促进预防性公共卫生战略的方法。
In this article, we report the different presentations of thiamine deficiency disorders seen at a remote rural mission hospital in Northeast India, including investigations, treatment, and recovery. Two case studies, one of an infant with cardiac beriberi and the other of a nonalcoholic adult presenting with peripheral neuropathy, cardiomyopathy, and metabolic acidosis and responding to thiamine supplementation, are described in detail. We share our experience with these clinical entities over the past two decades, including recent research and lessons learned, and suggest ways forward to identify at-risk populations in Northeast India, improve early diagnosis and treatment, and promote preventive public health strategies.