Patterns of gray matter atrophy in atypical parkinsonism syndromes: a VBM meta-analysis.
Patterns of gray matter atrophy in atypical parkinsonism syndromes: a VBM meta-analysis.
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DOI：
10.1002/brb3.329
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发表时间：
2015-06
影响因子：
3.1
通讯作者：
Fox, Peter
中科院分区：
文献类型：
--
作者：
Yu, Fang;Barron, Daniel S.;Tantiwongkosi, Bundhit;Fox, Peter
非典型帕金森综合征（APS）的准确诊断是重要的，由于预后和管理的差异，但在临床上仍然是一个挑战。本荟萃分析的目的是确定皮质基底节变性（CBD）、进行性核上性麻痹（PSP）、多系统萎缩性帕金森病型（MSA-P）和特发性帕金森病（IPD）中灰质萎缩的特征模式。使用修改后的解剖似然估计方法对39篇已发表的基于体素的形态测量（VBM）文章（包括404篇IPD、87篇MSA-P、165篇CBD和176篇PSP受试者）进行了全脑荟萃分析。基于这些结果，然后利用对比分析来确定每种疾病共有的以及独特的萎缩区域。CBD的特征是多个皮质区域的不对称灰质萎缩，而丘脑-中脑和丘脑主要参与PSP。纹状体和上级小脑的影响，而IPD表现出大脑前部的模式。虽然PSP、CBD和MSA-P之间存在轻度重叠，但确定了每种疾病特有的显著萎缩区域，包括（1）CBD的上级顶叶（2）MSA-P的壳核（3）PSP的背内侧核和内侧背核。我们的研究结果表明，有特征性的模式萎缩在APS。在这些发现的指导下，未来对个体受试者水平的研究可能会导致开发出强大的成像生物标志物。
Accurate diagnosis of Atypical Parkinsonian Syndromes (APS) is important due to differences in prognosis and management, but remains a challenge in the clinical setting. The purpose of our meta-analysis was to identify characteristic patterns of gray matter atrophy in Corticobasal Degeneration (CBD), Progressive Supranuclear Palsy (PSP), Multisystem-Atrophy Parkinsonian type (MSA-P), and Idiopathic Parkinson's Disease (IPD). Whole-brain meta-analysis was performed on 39 published voxel-based morphometry (VBM) articles (consisting of 404 IPD, 87 MSA-P, 165 CBD, and 176 PSP subjects) using the modified Anatomic Likelihood Estimation method. Based on these results, contrast analyses were then utilized to determine areas of atrophy shared by as well as unique to each disorder. CBD was characterized by asymmetric gray matter atrophy in multiple cortical regions, while the thalamus-midbrain and insula were predominantly involved in PSP. The striatum and superior cerebellum were affected in MSA-P, while IPD demonstrated an anterior cerebral pattern. Although there was a mild overlap among PSP, CBD, and MSA-P, significant regions of atrophy unique to each disorder were identified, including (1) the superior parietal lobule in CBD (2) putamen in MSA-P (3) insula and medial dorsal nucleus in PSP. Our results suggest that there are characteristic patterns of atrophy in APS. Guided by these findings, future studies on the individual subject level may lead to the development of robust imaging biomarkers.
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影响因子：
4.8
作者：
Eickhoff, Simon B.;Laird, Angela R.;Grefkes, Christian;Wang, Ling E.;Zilles, Karl;Fox, Peter T.
通讯作者：
Fox, Peter T.
影响因子：
4.2
作者：
Atluri, Gowtham;Padmanabhan, Kanchana;Fang, Gang;Steinbach, Michael;Petrella, Jeffrey R.;Lim, Kelvin;MacDonald, Angus, III;Samatova, Nagiza F.;Doraiswamy, P. Murali;Kumar, Vipin
通讯作者：
Kumar, Vipin
影响因子：
6
作者：
Forman, MS;Zhukareva, V;Trojanowski, JQ
通讯作者：
Trojanowski, JQ
影响因子：
9.9
作者：
Kraft, E;Trenkwalder, C;Auer, DP
通讯作者：
Auer, DP
影响因子：
--
作者：
Jankovic, J;Rajput, AH;Perl, DP
通讯作者：
Perl, DP