Incidence of seed migration to the chest, abdomen, and pelvis after transperineal interstitial prostate brachytherapy with loose 125I seeds
Incidence of seed migration to the chest, abdomen, and pelvis after transperineal interstitial prostate brachytherapy with loose 125I seeds
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DOI：
10.1186/1748-717x-6-130
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发表时间：
2011-10-05
影响因子：
3.6
通讯作者：
Shigematsu, Naoyuki
中科院分区：
文献类型：
--
作者：
Sugawara, Akitomo;Nakashima, Jun;Shigematsu, Naoyuki
背景资料：目的是确定种子迁移的发病率，不仅胸部，但也到腹部和骨盆后，经会阴间质前列腺近距离放射治疗与松散的I-125 seeds.Methods：我们回顾了267例患者接受前列腺近距离放射治疗与松散的I-125种子。粒子植入后，常规进行正交胸片、腹部X线片和骨盆X线片，以记录粒子迁移的发生和部位。计算了放射性粒子迁移至胸部、腹部和骨盆的发生率。所有粒子迁移到腹部和骨盆的患者随后都接受了计算机断层扫描，以确定迁移粒子的确切位置。植入后进行了剂量学分析，并对有和无粒子迁移的患者进行了剂量学结果比较。总体而言，267名患者中有66名（24.7%）患者的19，236粒种子中有91粒（0.47%）发生迁移。54例（20.2%）患者中69例（0.36%）粒子迁移至胸部。6例（2.2%）患者中有7例（0.036%）粒子迁移至腹部。15例（5.6%）患者的15个（0.078%）粒子迁移至骨盆。种子迁移主要发生在种子植入后两周内。66名患者均未出现与移动的粒子相关的症状。植入后前列腺D90在有和没有粒子迁移的患者之间没有显著差异。结论：我们显示了粒子迁移到胸部、腹部和骨盆的发生率。种子迁移对植入后前列腺D90无显著影响。
Background: The aim was to determine the incidence of seed migration not only to the chest, but also to the abdomen and pelvis after transperineal interstitial prostate brachytherapy with loose I-125 seeds.Methods: We reviewed the records of 267 patients who underwent prostate brachytherapy with loose I-125 seeds. After seed implantation, orthogonal chest radiographs, an abdominal radiograph, and a pelvic radiograph were undertaken routinely to document the occurrence and sites of seed migration. The incidence of seed migration to the chest, abdomen, and pelvis was calculated. All patients who had seed migration to the abdomen and pelvis subsequently underwent a computed tomography scan to identify the exact location of the migrated seeds. Postimplant dosimetric analysis was undertaken, and dosimetric results were compared between patients with and without seed migration.Results: A total of 19,236 seeds were implanted in 267 patients. Overall, 91 of 19,236 (0.47%) seeds migrated in 66 of 267 (24.7%) patients. Sixty-nine (0.36%) seeds migrated to the chest in 54 (20.2%) patients. Seven (0.036%) seeds migrated to the abdomen in six (2.2%) patients. Fifteen (0.078%) seeds migrated to the pelvis in 15 (5.6%) patients. Seed migration occurred predominantly within two weeks after seed implantation. None of the 66 patients had symptoms related to the migrated seeds. Postimplant prostate D90 was not significantly different between patients with and without seed migration.Conclusion: We showed the incidence of seed migration to the chest, abdomen and pelvis. Seed migration did not have a significant effect on postimplant prostate D90.