Normal structure, function, and histology of mucosa-associated lymphoid tissue
Normal structure, function, and histology of mucosa-associated lymphoid tissue
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DOI：
10.1080/01926230600865531
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发表时间：
2006-01-01
影响因子：
1.5
通讯作者：
Cesta, Mark F.
中科院分区：
文献类型：
--
作者：
Cesta, Mark F.
粘膜相关淋巴组织（MALT）启动对沿着所有粘膜表面遇到的特异性抗原的免疫应答。MALT诱导位点是次级免疫组织，其中发生抗原取样并启动免疫应答。效应位点作为沿着所有粘膜表面的弥漫性淋巴组织存在，是伊加转运穿过粘膜上皮的位点。虽然在不同器官中的诱导位点之间存在许多差异，但它们都包含相同的基本区室-卵泡、卵泡间区、上皮下圆顶区和卵泡相关上皮。MALT和其他次级淋巴组织之间的形态学差异，不同解剖位置的MALT网站之间，和实验室动物之间的物种差异进行了描述。MALT的形态学变化与衰老、营养途径和基因突变（即，裸和SCID突变）也进行了讨论。MALT组织包括粘膜免疫系统，其可以独立于全身免疫系统发挥作用，因此是免疫病理学的重要且经常被忽视的方面。
The mucosa-associated lymphoid tissue (MALT) initiates immune responses to specific antigens encountered along all mucosal surfaces. MALT inductive sites are secondary immune tissues where antigen sampling occurs and immune responses are initiated. Effector sites, present as diffuse lymphoid tissue along all mucosal surfaces are the sites of IgA transport across the mucosal epithelium. Though there are many differences between inductive sites in various organs, they all contain the same basic compartments-follicles, interfollicular regions, subepithelial dome regions, and follicle-associated epithelium. The morphologic differences between MALT and other secondary lymphoid tissues, between the MALT sites of differing anatomic locations, and species differences among laboratory animals are described. The morphologic changes in MALT associated with aging, route of nutrition, and genetic mutation (i.e., the nude and SCID mutations) are also discussed. MALT tissues comprise the mucosal immune system which can function independently of the systemic immune system and are, therefore, an important and often overlooked aspect of immunopathology.