Assessment of renal hemodynamics and function in pigs with 64-section multidetector CT: Comparison with electron-beam CT
Assessment of renal hemodynamics and function in pigs with 64-section multidetector CT: Comparison with electron-beam CT
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DOI：
10.1148/radiol.2432060655
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发表时间：
2007-05-01
期刊：
影响因子：
19.7
通讯作者：
Lerman, Lilach O.
中科院分区：
文献类型：
--
作者：
Daghini, Elena;Primak, Andrew N.;Lerman, Lilach O.
用途：为了前瞻性地评估获得可靠的测量肾血流动力学和功能的可行性，通过使用64节多排CT. Materials和Methods：这项研究是由机构动物护理和使用委员会批准。8只猪（2只诱导单侧肾动脉狭窄）进行了研究，电子束CT和64节多层螺旋CT在1周的时间间隔随机顺序。在静脉（IV）注射造影剂后约3分钟，以及在血管扩张剂激发（乙酰胆碱）期间，重复扫描两个肾脏，不移动扫描床。在每个CT控制台上重建图像，但在同一独立工作站上分析。将肾脏的衰减变化绘制为时间的函数，随后分析时间-衰减曲线（TAC）以确定区域灌注和体积、肾小球滤过率（GFR）和肾血流量（RBF）。统计学分析采用学生t检验，方差分析（ANOVA），线性回归，和Bland-Altman analysis. Results：与多排CT获得的总可吸入颗粒物定性相似，与电子束CT获得的，作为肾灌注和功能的定量值。两种技术之间的RBF显著相关（RBFMD = 0.96（.）RBFEB mL/min; R = 0.77，P.05）。Bland-Altman图显示两种技术之间具有良好的一致性。这两种技术同样检测狭窄和对侧kidneas.Conclusion之间的差异：临床多排CT扫描仪提供了可靠的测量单肾血流动力学和功能，这是类似于以前验证的电子束CT获得的。(c)RSNA，2007年。
Purpose: To prospectively evaluate the feasibility of obtaining reliable measurements of renal hemodynamics and function by using 64-section multidetector CT.Materials and Methods: This study was approved by the Institutional Animal Care and Use Committee. Eight pigs ( two with induced unilateral renal artery stenosis) were studied with both electron-beam CT and 64-section multidetector CT at 1-week intervals in randomized order. Both kidneys were scanned repeatedly, without table movement, for about 3 minutes after intravenous ( IV) administration of a bolus of contrast medium and again during vasodilator challenge ( acetylcholine). Images were reconstructed on each CT console but were analyzed on the same independent workstation. Attenuation changes in the kidneys were plotted as function of time, and time-attenuation curves ( TACs) were subsequently analyzed to determine regional perfusion and volume, glomerular filtration rate ( GFR), and renal blood flow ( RBF). Statistical analysis utilized Student t test, analysis of variance ( ANOVA), linear regression, and Bland-Altman analysis.Results: TACs obtained with multidetector CT were qualitatively similar to those obtained with electron-beam CT, as were the quantitative values of renal perfusion and function. RBF correlated significantly between the two techniques ( RBFMD = 0.96 (.) RBFEB mL/min; R = 0.77, P .05). Bland-Altman plots showed good agreement between the two techniques. Both techniques similarly detected the differences between stenotic and contralateral kidneys.Conclusion: The clinical multidetector CT scanner provides reliable measurements of single-kidney hemodynamics and function, which are similar to those obtained with previously validated electron-beam CT. (c) RSNA, 2007.