Highly Diastereoselective Synthesis of Atropisomeric Bridged P,N-Ligands and Their Applications in Asymmetric Suzuki–Miyaura Coupling Reaction
Highly Diastereoselective Synthesis of Atropisomeric Bridged P,N-Ligands and Their Applications in Asymmetric Suzuki–Miyaura Coupling Reaction
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DOI：
10.1002/adsc.201200095
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发表时间：
2012-09
影响因子：
5.4
通讯作者：
Wenhao Wu;Shou‐Guo Wang;You‐Yun Zhou;Yuwei He;Zhuang Yue;Lanning Li;P. Wan;L. Wang;Zhongyuan Zhou;L. Qiu
中科院分区：
文献类型：
--
作者：
Wenhao Wu;Shou‐Guo Wang;You‐Yun Zhou;Yuwei He;Zhuang Yue;Lanning Li;P. Wan;L. Wang;Zhongyuan Zhou;L. Qiu
采用高效的中心-轴向转移策略合成了三种新型阻转异构桥联P，N-配体。并将其应用于钯催化的不对称Suzuki-Miyaura偶联反应中，对映选择性合成了轴向手性双芳基膦酸酯，收率达98%，ee值达82%。
Three novel atropisomeric bridged P,N-ligands were prepared using a highly efficient central-to-axial transfer strategy as the protocol. The new chiral ligands were successfully applied in the palladium-catalyzed asymmetric Suzuki–Miyaura coupling reaction, Up to 98% yield and 82% ee were obtained in the enantioselective synthesis of axially chiral biarylphosphonates.