Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates
Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates
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DOI：
10.1038/sj.mp.4001157
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发表时间：
2002-01-01
影响因子：
11
通讯作者：
Suomi, SJ
中科院分区：
文献类型：
--
作者：
Champoux, M;Bennett, A;Suomi, SJ
5-羟色胺(5-羟色胺)转运体基因调控区(5-HTTLPR)的多态与人类5-羟色胺转运体(5-HTT)的表达和5-羟色胺(5-HT)介导的行为有关。在恒河猴(RH5-HTTLPR)中也报道了类似的5-HTTLPR长度变异。对115例长5HTTLPR纯合子(I/I)和短长杂合子(I/S)猕猴婴儿进行了回顾性关联研究。为了评估基因和早期饲养环境的影响，对36只母养猴(I/I=26，I/S=10)和79只育成猴(I/I=54，I/S=25)在出生第7、14、21和30天进行了标准化的灵长类神经行为测试，该测试旨在测量定向、运动成熟度、反射功能和气质。与I/I纯合子相比，母亲饲养的和苗圃饲养的杂合子动物都表现出更高的情感反应。在婴儿期养育，而不是在母亲养育下，IN婴儿的定向得分低于I/I婴儿。这些结果表明，在一个非人类灵长类动物的行为发育模型中，养育环境和遗传背景以及它们之间的相互作用是有贡献的。
A polymorphism in the serotonin (5-HT) transporter gene regulatory region (5-HTTLPR) is associated with measures of 5-HT transporter (5-HTT) expression and 5-HT-mediated behaviors in humans. An analogous length variation of the 5-HTTLPR has been reported in rhesus monkeys (rh5-HTTLPR). A retrospective association study was conducted on 115 rhesus macaque infants either homozygous for the long 5HTTLPR variant (I/I) or heterozygous for the short and long form (I/s). To assess contributions of genotype and early rearing environment, 36 mother-reared monkeys (I/I = 26, I/s = 10) and 79 nursery-reared monkeys (I/I = 54, I/s = 25) were assessed on days 7, 14, 21, and 30 of life on a standardized primate neurobehavioral test designed to measure orienting, motor maturity, reflex functioning, and temperament. Both mother-reared and nursery-reared heterozygote animals demonstrated increased affective responding relative to I/I homozygotes. Nursery-reared, but not mother-reared, IN infants exhibited lower orientation scores than their I/I counterparts. These results demonstrate the contributions of rearing environment and genetic background, and their interaction, in a nonhuman primate model of behavioral development.