Follicular somatic cell factors and follicle development
Follicular somatic cell factors and follicle development
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DOI：
10.1071/rd10224
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发表时间：
2011-01-01
影响因子：
1.9
通讯作者：
Price, C. A.
中科院分区：
文献类型：
--
作者：
Buratini, J., Jr.;Price, C. A.
目前，作用于卵丘和颗粒细胞的卵母细胞来源的分泌因子受到相当大的关注。对卵泡发育也很重要的是体细胞来源的分泌因子。颗粒细胞衍生的Kit配体(KITL)促进原始卵泡激活的能力，以及伴随KITL基因破坏而导致的卵泡发育丧失，说明了这一点。本文综述了目前对腔前和腔内卵泡生长过程中体细胞因子的认识，不仅涉及颗粒细胞到卵母细胞的信号传递，还涉及颗粒细胞和卵膜细胞之间的信号传递。颗粒细胞来源的主要因子包括激活素、抗苗勒氏激素(AMH)、骨形态发生蛋白(BMPs)和成纤维细胞生长因子(FGFs)。卵泡膜细胞还分泌BMP和FGFs。这些因素之间的相互作用对卵泡生长和卵母细胞衍生因子的活性同样重要。
Considerable attention is currently paid to oocyte-derived secreted factors that act upon cumulus and granulosa cells. Also important for follicle development are somatic cell-derived secreted factors. This is illustrated by the ability of granulosa cell-derived Kit ligand (KITL) to promote primordial follicle activation, and the loss of follicle development that accompanies KITL gene disruption. This review summarises our current understanding of somatic cell factors during both preantral and antral follicle growth, involving not only signalling from granulosa cells to the oocyte, but also signalling between granulosa and theca cells. Principal granulosa cell-derived factors include activin, anti-Mullerian hormone (AMH), bone morphogenetic proteins (BMPs) and fibroblast growth factors (FGFs). Theca cells also secrete BMPs and FGFs. The interplay between these factors is equally important for follicle growth as the activity of oocyte-derived factors.