The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3.
The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3.
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DOI：
10.1084/jem.20030107
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发表时间：
2003-07-21
期刊：
影响因子：
--
通讯作者：
Wu L
中科院分区：
文献类型：
--
作者：
D'Amico A;Wu L
Flt 3配体（Flt 3L）是造血祖细胞的生长因子，并且可以促进常规树突状细胞（DC）和浆细胞样前树突状细胞（p-preDC）的扩增。响应Flt 3L处理的细胞以及DC和p-preDC的前体尚未完全表征。我们检查了不同的小鼠骨髓（BM）造血前体群体的Flt 3的表面表达，并测试了它们的早期DC和p-preDC前体活性。大多数DC前体活性，而不是由多能造血干细胞，是在下游前体表达Flt 3。大多数小鼠BM共同淋巴前体表达高水平的Flt 3，并且这些是DC和p-preDC两者的最有效的前体。相比之下，只有一小部分常见的髓样前体（CMP）表达Flt 3，但DC和p-preDC的前体活性都在这个较小的Flt 3 + CMP部分内。粒细胞和巨噬细胞前体和前B细胞不表达Flt 3，并且没有DC或p-preDC前体活性。这些发现表明，所有DC亚型的早期前体都在BM Flt 3+前体群体内，而不管它们的淋巴或骨髓谱系取向如何。
Flt3 ligand (Flt3L) is a growth factor for hemopoietic progenitors and can promote the expansion of both conventional dendritic cells (DCs) and plasmacytoid predendritic cells (p-preDCs). The cells responding to Flt3L treatment and the precursors for the DCs and p-preDCs had not been fully characterized. We examined different mouse bone marrow (BM) hemopoietic precursor populations for the surface expression of Flt3 and tested them for early DC and p-preDC precursor activity. Most DC precursor activity, other than that given by multipotent hemopoietic stem cells, was within the downstream precursors expressing Flt3. The majority of mouse BM common lymphoid precursors expressed high levels of Flt3 and these were the most efficient precursors of both DCs and p-preDCs. In contrast, only a small proportion of the common myeloid precursors (CMPs) expressed Flt3, but the precursor activity for both DCs and p-preDCs was within this minor Flt3+ CMP fraction. The granulocyte and macrophage precursors and pro-B cells did not express Flt3 and had no DC or p-preDC precursor activity. These findings demonstrate that the early precursors for all DC subtypes are within the BM Flt3+ precursor populations, regardless of their lymphoid or myeloid lineage orientation.
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DOI：
10.1084/jem.20020045
发表时间：
2002-04-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gilliet M;Boonstra A;Paturel C;Antonenko S;Xu XL;Trinchieri G;O'Garra A;Liu YJ
通讯作者：
Liu YJ
FLT3配体处理的小鼠功能成熟的树突状细胞数量的急剧增加：确定的多个树突状细胞亚群。
影响因子：
15.3
作者：
Maraskovsky, E;Brasel, K;Teepe, M;Roux, ER;Lyman, SD;Shortman, K;McKenna, HJ
通讯作者：
McKenna, HJ
影响因子：
3.2
作者：
McKenna, HJ
通讯作者：
McKenna, HJ
影响因子：
20.3
作者：
O'Keeffe, M;Hochrein, H;Shortman, K
通讯作者：
Shortman, K
影响因子：
4.4
作者：
Brawand, P;Fitzpatrick, DR;De Smedt, T
通讯作者：
De Smedt, T