Intravenous glargine and regular insulin have similar effects on endogenous glucose output and peripheral activation/deactivation kinetic profiles
Intravenous glargine and regular insulin have similar effects on endogenous glucose output and peripheral activation/deactivation kinetic profiles
复制标题
DOI：
10.2337/diacare.25.9.1597
复制
发表时间：
2002-09-01
期刊：
影响因子：
16.2
通讯作者：
Henry, RR
中科院分区：
文献类型：
--
作者：
Mudaliar, S;Mohideen, P;Henry, RR
目的-比较静脉注射长效甘精胰岛素类似物和常规人胰岛素对内源性葡萄糖输出（EGO）和外周葡萄糖摄取的激活和失活的影响。研究设计和方法-在这项单中心，随机，双盲，交叉正葡萄糖钳夹研究中，15名健康男性志愿者（年龄27 +/- 4岁，BMI 24.2 +/- 0.7 k g/m2 [平均值+/- SE]）在2个不同的研究日以随机顺序接受40 mU/m2甘精胰岛素或常规人胰岛素的预充持续静脉输注。通过同时可变静脉输注含D-[3（-3）H]葡萄糖的20%葡萄糖，将Euglycin维持在90 mg/dl。EGO和外周葡萄糖处置动力学测定在4小时胰岛素输注激活期和3小时deactivationperiod.RESULTS -结果表明没有显着差异，在激活或失活动力学相对于EGO和外周葡萄糖处置甘精胰岛素和普通人胰岛素静脉注射时。胰岛素输注后达到50% EGO抑制所需的平均+/- SE时间，常规胰岛素为73 +/- 23 min，甘精胰岛素（NS）为57 +/- 20 min。平均最大葡萄糖处置率分别为10.10 +/- 0.77和9.90 +/- 0.85 mg。kg（-1）。对于常规胰岛素和甘精胰岛素，分别为min'（NS）。对于常规胰岛素和甘精胰岛素（NS），增量葡萄糖处置率（GDR）50%抑制所需的平均时间（定义为从基础葡萄糖消失率（R-d）激活至胰岛素刺激的半数最大R-d所需的时间）分别为32 +/- 5和42 +/- 10 min。对于常规胰岛素和甘精胰岛素，从最大胰岛素刺激的GDR到停止融合胰岛素后半最大GDR的失活所需时间分别为63 +/- 5和57 +/- 4 min，结论：当给药时，常规人胰岛素和甘精胰岛素之间EGO和外周葡萄糖摄取的激活和失活动力学以及绝对处置率相似静脉注射因此，这些胰岛素制剂在皮下给药时的各种生物学作用完全是由于其不同的吸收动力学。
OBJECTIVE- To compare the effects of intravenously administered long-acting insulin analog glargine and regular human insulin on activation and deactivation of endogenous glucose output (EGO) and peripheral glucose uptake.RESEARCH DESIGN AND METHODS- in this single-center, randomized, double-blind, crossover euglycemic glucose clamp study, 15 healthy male volunteers (aged 27 +/- 4 years, BMI 24.2 +/- 0.7 k g/m(2) [mean +/- SE]) received a primed continuous intravenous infusion of 40 mU/m(2) of insulin glargine or regular human insulin on 2 different study days in a randomized order. Euglycemia was maintained at 90 mg/dl using a simultaneous variable intravenous infusion of 20% dextrose containing D-[3(-3)H] glucose. EGO and peripheral glucose disposal kinetics were determined during a 4-h insulin infusion activation period and a 3-h deactivation period.RESULTS -The results demonstrated no significant difference in activation or deactivation kinetics With respect to EGO and peripheral glucose disposal between insulin glargine and regular human insulin when given intravenously. The mean +/- SE time required for 50% suppression of EGO after insulin infusion was 73 +/- 23 min for regular insulin and 57 +/- 20 min for insulin glargine (NS). The mean maximum rate of glucose disposal was 10.10 +/- 0.77 and 9.90 +/- 0.85 mg . kg(-1) . min' for regular insulin and insulin glargine, respectively (NS). The mean time required for 50% suppression of incremental glucose disposal rate (GDR), defined as the time required for activation from the basal glucose disappearance rate (R-d) to half-maximum insulin-stimulated R-d was 32 +/- 5 and 42 +/- 10 min for regular insulin and insulin glargine, respectively (NS). The time required for deactivation from maximum insulin-stimutated GDR to half-maximum GDR after cessation of insulin in fusion was 63 +/- 5 and 57 +/- 4 min for regular insulin and insulin glargine, respectively (NS).CONCLUSIONS- Activation and deactivation kinetics of EGO and peripheral glucose uptake as well as absolute disposal rate are similar between regular human insulin and insulin glargine when administered intravenously. Thus, the various biological actions of these insulin preparations when given subcutaneously are completely due to their different absorption kinetics.