Evaluation of the internal fixation effect of nano-calcium-deficient hydroxyapatite/poly-amino acid composite screws for intraarticular fractures in rabbits.
Evaluation of the internal fixation effect of nano-calcium-deficient hydroxyapatite/poly-amino acid composite screws for intraarticular fractures in rabbits.
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DOI：
10.2147/ijn.s173358
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发表时间：
2018
影响因子：
8
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Dai Z;Li Y;Yan Y;Wan R;Ran Q;Lu W;Qiao B;Li H
评价纳米缺钙羟基磷灰石/聚氨基酸（n-CDHA/PAA）复合螺钉在关节内骨折模型中的内固定效果。 35只新西兰大白兔用于双侧股骨髁间骨折模型，随机分为两组。实验组使用n-CDHA/PAA螺钉，对照组使用医用金属螺钉。评估骨折情况、活动范围和螺钉推出强度，并于术后4、8、12周进行膝关节镜检查。通过称重测试n-CDHA/PAA螺钉体内的生物降解性，并在术后12周通过X射线衍射评估螺钉结构的变化。所有动物一般情况良好，术后无切口感染、裂开等情况。 X线扫描显示，术后4周两组均出现明显愈伤组织生长，术后各时间点实验组与对照组Lane-Sandhu评分差异均无统计学意义（P>0.05）。两组膝关节活动度及关节镜检查Oswestry关节镜评分差异均无统计学意义（P>0.05）。术后4周对照组螺钉推出力强于实验组（P<0.05），但术后4周后组间比较差异无统计学意义（P>0.05）。降解试验显示n-CDHA/PAA螺钉植入后逐渐降解，术后12周体重减轻率约为16%。 X射线衍射结果显示n-CDHA/PAA螺钉外表面的晶体结构在术后12周发生了变化。 n-CDHA/PAA螺钉是一种有效、安全的植入物，作为股骨髁间骨折潜在的内固定器械，其内固定效果与医用金属螺钉相似。
To evaluate the internal fixation effect of nano-calcium-deficient hydroxyapatite/poly-amino acid (n-CDHA/PAA) composite screws in the intraarticular fracture model. A total of 35 New Zealand White rabbits were used in a bilateral femoral intercondylar fracture model and randomly divided into two groups. n-CDHA/PAA screws were used in the experimental group, and medical metal screws were used in the control group. The fracture condition, range of motion, and the screw push-out strength were assessed, and an arthroscopic examination of knee joint was performed at 4, 8, and 12 weeks after surgery. The biodegradation of the n-CDHA/PAA screws in vivo was tested through weighing, and changes in screw structure were assessed by X-ray diffraction at 12 weeks after surgery. The general situation of all animals was good and showed no incision infection and dehiscence after surgery. X-ray scanning showed that significant callus growth was present in both groups at 4 weeks after surgery, and there was no significant difference (P>0.05) in the Lane-Sandhu score between the experimental and control groups at all time points after surgery. There were no statistically significant differences (P>0.05) in the range of motion and Oswestry Arthroscopy Score of arthroscopic examination of the knee joints between the two groups. The screw push-out strength of the control group was stronger than that of the experimental group at 4 weeks after surgery (P<0.05), but after that, there was no significant difference between the groups (P>0.05). The degradation tests showed that the n-CDHA/PAA screws degraded gradually after implantation, and the weight loss rate was approximately 16% at 12 weeks after surgery. The X-ray diffraction results showed that the crystal structure of the outer surface of the n-CDHA/PAA screw has changed at 12 weeks after surgery. The n-CDHA/PAA screw is an effective and safe implant as a potential internal fixation device for an intercondylar fracture of the femur, and its internal fixation effect was similar to that of medical metal screw.