INTERLEUKIN-6 RESPONSE TO DELIBERATE COLONIZATION OF THE HUMAN URINARY-TRACT WITH GRAM-NEGATIVE BACTERIA
INTERLEUKIN-6 RESPONSE TO DELIBERATE COLONIZATION OF THE HUMAN URINARY-TRACT WITH GRAM-NEGATIVE BACTERIA
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DOI：
10.1128/iai.59.1.421-427.1991
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发表时间：
1991-01-01
影响因子：
3.1
通讯作者：
SVANBORG, C
中科院分区：
文献类型：
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作者：
HEDGES, S;ANDERSON, P;SVANBORG, C
膀胱内接种大肠杆菌的患者提供了一个机会，检查白细胞介素-6（IL-6）的反应，革兰氏阴性细菌尿路感染的人。 所有患者由于感染而分泌IL-6。 尿IL-6不是连续分泌的，而是在感染后的第一个48小时内出现一系列相似的峰。 在同基因粘附或非粘附菌株之间，触发IL-6分泌的能力没有显著差异，但每ml尿液中10（5）个细菌的阈值浓度是完全刺激IL-6分泌所必需的。 有没有可检测到的增加IL-6水平的血清中的殖民化的个人，这表明主要是本地IL-6的生产。 这些结果表明，IL-6是革兰氏阴性尿路感染的人粘膜反应的一部分。
Intravesical inoculation of patients with Escherichia coli provided an opportunity to examine the interleukin-6 (IL-6) response to a gram-negative bacterial urinary tract infection in humans. All patients secreted IL-6 as a result of infection. Urinary IL-6 was not continuously secreted but appeared as a series of similar peaks during the first 48 h after infection. There was no significant difference in the ability to trigger IL-6 secretion between isogenic adhering or nonadhering strains, but a threshold concentration of 10(5) bacteria per ml of urine was necessary to fully stimulate IL-6 secretion. There was no detectable increase in IL-6 levels in the serum of the colonized individuals, suggesting mainly local IL-6 production. These results demonstrate that IL-6 is a part of the human mucosal response to gram-negative urinary tract infections.