Biofilm delays wound healing: A review of the evidence.
Biofilm delays wound healing: A review of the evidence.
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DOI：
10.4103/2321-3868.113329
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发表时间：
2013
期刊：
影响因子：
5.3
通讯作者：
Bowler PG
中科院分区：
文献类型：
--
作者：
Metcalf DG;Bowler PG
生物膜是细菌的主要生活方式，今天它与许多人类疾病有关。关于伤口中生物膜的存在，现在存在越来越多的科学和临床证据。这篇综述总结了临床经验和体内证据表明，生物膜在延迟伤口愈合。强调了生物膜可能阻碍愈合的各种机制，包括上皮形成和肉芽组织形成受损，以及对抗菌剂和宿主防御的敏感性降低。管理生物膜和鼓励伤口愈合进展的策略进行了讨论，其中包括清创术和适当的抗菌治疗，这可能会在未来随着抗生物膜技术的出现而得到改善。
Biofilm is the predominant mode of life for bacteria and today it is implicated in numerous human diseases. A growing body of scientific and clinical evidence now exists regarding the presence of biofilm in wounds. This review summarizes the clinical experiences and in vivo evidence that implicate biofilm in delayed wound healing. The various mechanisms by which biofilm may impede healing are highlighted, including impaired epithelialization and granulation tissue formation, and reduced susceptibilities to antimicrobial agents and host defenses. Strategies to manage biofilm and encourage progression to wound healing are discussed; these include debridement and appropriate antimicrobial therapies which may be improved upon in the future with the emergence of anti-biofilm technologies.