Synaptic tagging: implications for late maintenance of hippocampal long-term potentiation
Synaptic tagging: implications for late maintenance of hippocampal long-term potentiation
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DOI：
10.1016/s0166-2236(97)01189-2
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发表时间：
1998-05-01
影响因子：
15.9
通讯作者：
Morris, RGM
中科院分区：
文献类型：
--
作者：
Frey, U;Morris, RGM
最近描述了海马LTP的一种新特性--可变持久性，我们认为，这与LTP在信息存储中的作用有关。具体地说，新的结果表明，突触激活的一种特定模式可以产生相对较短的LTP，也可以作为神经元激活历史的函数而产生较长的LTP。这导致了这样一种想法，即LTP的诱导与在激活的突触上设置“突触标签”有关，突触标签的作用是隔离可塑性相关的蛋白，然后这些蛋白起到稳定暂时性突触变化的作用，从而延长其持久性。在这篇文章中，我们概述了突触标签假说，比较了它与其他关于LTP持续性的理论的预测，并推测了标签的细胞身份。此外，我们概述了诱导晚期LIP所需的胺能激活，并考虑了突触标记假说对长期记忆的功能影响。
A novel property of hippocampal LTP, 'variable persistence', has recently been described that is, we argue, relevant to the role of LTP in information storage. Specifically, new results indicate that a particular pattern of synaptic activation can give rise, either to a relatively short-lasting LTP, or to a longer-lasting LTP as a function of the history of activation of the neuron. This has led to the idea that the induction of LTP is associated with the setting of a 'synaptic tag' at activated synapses, whose role is to sequester plasticity-related proteins that then serve to stabilize temporary synaptic changes and so extend their persistence. In this article, we outline the synaptic tag hypothesis, compare predictions it makes with those of other theories about the persistence of LTP, and speculate about the cellular identity of the tag. In addition, we outline the requirement for aminergic activation to induce late LIP and consider the functional implications of the synaptic tag hypothesis with respect to long-term memory.