Gene therapy for cardiac arrhythmias
Gene therapy for cardiac arrhythmias
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DOI：
10.1196/annals.1302.029
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Donahue, JK
中科院分区：
文献类型：
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作者：
Donahue, JK
心肌基因转移在研究心脏疾病的病理生理和潜在治疗方面显示出巨大的潜力。在心律失常领域，存在对新的治疗选择的巨大需求。本文综述了心律失常新疗法的必要性、利用基因转移评估细胞电生理学、体内基因转移在常见心律失常治疗中的应用以及心脏基因治疗领域存在的问题。心律失常基因治疗是一个处于起步阶段的领域，未来的人类应用取决于这里讨论的问题的解决方案。
Myocardial gene transfer has shown tremendous potential to investigate pathophysiology and potential therapies for cardiac diseases. In the field of cardiac arrhythmias, there is a tremendous need for new therapeutic options. The current work reviews the need for new therapies for cardiac arrhythmias, the use of gene transfer to evaluate cellular electrophysiology, the application of in vivo gene transfer to treatment of common arrhythmias, and the current problems in the field of cardiac gene therapy. Arrhythmia gene therapy is a field in its infancy, and future human applications are dependent on solutions to the problems discussed here.