A DROSOPHILA MUTATION THAT ELIMINATES A CALCIUM-DEPENDENT POTASSIUM CURRENT
A DROSOPHILA MUTATION THAT ELIMINATES A CALCIUM-DEPENDENT POTASSIUM CURRENT
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DOI：
10.1073/pnas.83.21.8415
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发表时间：
1986-11-01
影响因子：
11.1
通讯作者：
WU, CF
中科院分区：
文献类型：
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作者：
ELKINS, T;GANETZKY, B;WU, CF
果蝇的一个突变，slo(Slo)，特异性地取消了成年果蝇背侧纵向飞行肌肉的钙依赖K+电流IC。其他K+电流保持正常，这为IC是由一组分子上可区分的通道介导的提供了证据。IC的药理特性类似于某些脊椎动物细胞上的钙依赖电流。肌肉动作电位显著延长，提示IC在其复极过程中起主要作用。
A mutation of Drosophila, slowpoke (slo), specifically abolishes a Ca2+-dependent K+ current, IC, from dorsal longitudinal flight muscles of adult flies. Other K+ currents remain normal, providing evidence that IC is mediated by a molecularly distinguishable set of channels. The pharmacological properties of IC are similar to those of Ca2+-dependent currents in some vertebrate cells. The muscle action potential was significantly lengthened in slo flies, indicating that IC plays the major role in its repolarization.