Effects of hypothermia on NSE and S-100 protein levels in CSF in neonates following hypoxic/ischaemic brain damage
Effects of hypothermia on NSE and S-100 protein levels in CSF in neonates following hypoxic/ischaemic brain damage
复制标题
低温对新生儿缺氧/缺血性脑损伤后脑脊液中 NSE 和 S-100 蛋白水平的影响
DOI：
10.1111/j.1651-2227.2012.02679.x
复制
发表时间：
2012-08-01
期刊：
影响因子：
3.8
通讯作者：
Zhou, Wenhao
中科院分区：
文献类型：
--
作者：
Sun, Jinqiao;Li, Jin;Zhou, Wenhao
目的：本研究旨在探讨低温对缺氧缺血性脑病（HIE）新生儿脑脊液（CSF）中神经元特异性烯醇化酶（NSE）和S-100蛋白水平的影响。方法：将51例HIE患儿随机分为亚低温组（n = 23）和对照组（n = 28）。免疫放射法测定NSE和S-100蛋白。氨基酸神经递质也通过反相高效液相色谱法测定。在3个月和12个月大时进行神经发育评估。结果如下：与对照组相比，低温组神经元特异性烯醇化酶和S-100水平较低，神经发育结局较好。在接受低温治疗的婴儿中，发生严重神经功能损害（智力发育指数或身体发育指数）的婴儿的CSF NSE和S-100显著升高
Aim: The aim of the study was to evaluate the effects of hypothermia on neuron-specific enolase (NSE) and S-100 protein levels in cerebrospinal fluid (CSF) in neonates with hypoxic/ischaemic encephalopathy (HIE). Methods: Fifty-one enrolled neonates with HIE were divided into two groups: hypothermia (n = 23) and control (n = 28). NSE and S-100 protein were measured with immunoradiometric assays. Amino acid neurotransmitters were also measured by reversed-phase high-performance liquid chromatography. Neurodevelopmental assessments were performed at 3 and 12 months of age. Results: Neuron-specific enolase and S-100 levels were lower, and neurodevelopment outcome was better in the hypothermia group compared with the control group. Among the infants who received hypothermia, CSF NSE and S-100 were significantly higher in those who developed severe neurological impairment (mental development index or physical development index