Iron deficiency in infancy and neurocognitive functioning at 19 years: evidence of long-term deficits in executive function and recognition memory.
Iron deficiency in infancy and neurocognitive functioning at 19 years: evidence of long-term deficits in executive function and recognition memory.
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DOI：
10.1179/147683010x12611460763689
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发表时间：
2010-04
影响因子：
3.6
通讯作者：
Lozoff B
中科院分区：
文献类型：
--
作者：
Lukowski AF;Koss M;Burden MJ;Jonides J;Nelson CA;Kaciroti N;Jimenez E;Lozoff B
婴儿期缺铁会对营养不足时期的各种神经发育过程产生负面影响，尽管进行了铁治疗，但仍会出现持续的中枢神经系统改变和行为功能缺陷。在啮齿动物模型中，早期缺铁会损害海马和多巴胺系统。我们研究了在婴儿时期经历过慢性严重缺铁的年轻人可能在记录在案的额纹状体（轨迹制造测试、内/外维转移、剑桥长袜、空间工作记忆、快速视觉信息处理）和海马体特异性（模式识别记忆、空间识别记忆）的神经认知测试中表现出缺陷的可能性。婴儿期慢性严重缺铁的参与者在额纹状体介导的执行功能（包括抑制控制、设定转移和计划）上表现不佳。还有证据表明，在基于海马体的识别记忆任务中也存在损伤。我们认为这些缺陷可能是由于早期缺铁对多巴胺系统、海马及其相互作用的长期影响。
Iron deficiency in infancy negatively impacts a variety of neurodevelopmental processes at the time of nutrient insufficiency, with persistent central nervous system alterations and deficits in behavioral functioning, despite iron therapy. In rodent models, early iron deficiency impairs the hippocampus and the dopamine system. We examined the possibility that young adults who had experienced chronic, severe iron deficiency as infants would exhibit deficits on neurocognitive tests with documented frontostriatal (Trail Making Test, Intra-/Extra-dimensional Shift, Stockings of Cambridge, Spatial Working Memory, Rapid Visual Information Processing) and hippocampal specificity (Pattern Recognition Memory, Spatial Recognition Memory). Participants with chronic, severe iron deficiency in infancy performed less well on frontostriatal-mediated executive functions, including inhibitory control, set-shifting, and planning. There was also evidence of impairment on a hippocampus-based recognition memory task. We suggest that these deficits may result from the long-term effects of early iron deficiency on the dopamine system, the hippocampus, and their interaction.